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    CABLES2 Cdk5 and Abl enzyme substrate 2 [ Homo sapiens (human) ]

    Gene ID: 81928, updated on 4-Mar-2018
    Official Symbol
    CABLES2provided by HGNC
    Official Full Name
    Cdk5 and Abl enzyme substrate 2provided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000149679 Vega:OTTHUMG00000032912
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ik3-2; C20orf150; dJ908M14.2
    Broad expression in testis (RPKM 25.7), heart (RPKM 3.5) and 19 other tissues See more
    Exon count:
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (62388630..62407283, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60963686..60982339, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372708 Neighboring gene ribosomal protein S21 Neighboring gene uncharacterized LOC105372709 Neighboring gene RBBP8 N-terminal like Neighboring gene uncharacterized LOC105372710

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog
    Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
    NHGRI GWA Catalog
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    Products Interactant Other Gene Complex Source Pubs Description



    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    cell division IEA
    Inferred from Electronic Annotation
    more info
    regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    Preferred Names
    CDK5 and ABL1 enzyme substrate 2
    interactor with CDK3 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031215.2NP_112492.2  CDK5 and ABL1 enzyme substrate 2

      See identical proteins and their annotated locations for NP_112492.2

      Status: VALIDATED

      Source sequence(s)
      AI066606, AL121832, BC003122, CB960872
      Consensus CDS
      ENSP00000279101.5, OTTHUMP00000031481, ENST00000279101.9, OTTHUMT00000080027
      Conserved Domains (2) summary
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly


    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      62388630..62407283 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1


    1. NC_018931.2 Alternate CHM1_1.1

      60864874..60883540 complement
      GenBank, FASTA, Sequence Viewer (Graphics)
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