Format

Send to:

Choose Destination
    • Showing Current items.

    XPNPEP2 X-prolyl aminopeptidase 2 [ Homo sapiens (human) ]

    Gene ID: 7512, updated on 3-Apr-2018
    Official Symbol
    XPNPEP2provided by HGNC
    Official Full Name
    X-prolyl aminopeptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:12823
    See related
    Ensembl:ENSG00000122121 MIM:300145; Vega:OTTHUMG00000022373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APP2; AEACEI
    Summary
    Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in small intestine (RPKM 88.3), kidney (RPKM 85.4) and 1 other tissue See more
    Orthologs
    Location:
    Xq26.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (129738970..129769549)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (128872946..128903525)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene apelin Neighboring gene uncharacterized LOC105373334 Neighboring gene SAM and SH3 domain containing 3 Neighboring gene zinc finger DHHC-type containing 9

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (XPNPEP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystem (from REACTOME)
      Post-translational modification: synthesis of GPI-anchored proteins, organism-specific biosystemGlycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactio...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aminopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    C-terminal protein lipidation TAS
    Traceable Author Statement
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome HDA PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    xaa-Pro aminopeptidase 2
    Names
    X-Pro aminopeptidase 2
    X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
    aminoacylproline aminopeptidase
    mAmP
    membrane-bound APP
    membrane-bound AmP
    membrane-bound aminopeptidase P
    NP_003390.4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011479.1 RefSeqGene

      Range
      5001..35580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003399.5NP_003390.4  xaa-Pro aminopeptidase 2 precursor

      See identical proteins and their annotated locations for NP_003390.4

      Status: REVIEWED

      Source sequence(s)
      AL023653, BF830085, BP270314, BQ224207, BX386512, CD617070, U90724
      Consensus CDS
      CCDS14613.1
      UniProtKB/Swiss-Prot
      O43895
      Related
      ENSP00000360147.3, OTTHUMP00000023987, ENST00000371106.3, OTTHUMT00000058210
      Conserved Domains (5) summary
      COG0006
      Location:348601
      PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
      cd01085
      Location:365583
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:54184
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:585648
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:202361
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

      Range
      129738970..129769549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center