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    Psd2 pleckstrin and Sec7 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 74002, updated on 27-Jan-2018
    Official Symbol
    Psd2provided by MGI
    Official Full Name
    pleckstrin and Sec7 domain containing 2provided by MGI
    Primary source
    MGI:MGI:1921252
    See related
    Ensembl:ENSMUSG00000024347 Vega:OTTMUSG00000042038
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EFA6C; AW125584; 6330404E20Rik
    Expression
    Biased expression in cerebellum adult (RPKM 18.6), CNS E18 (RPKM 14.6) and 6 other tissues See more
    Orthologs
    Location:
    18; 18 B2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (35964506..36014715)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (36124489..36174369)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36416 Neighboring gene predicted gene, 36461 Neighboring gene neuregulin 2 Neighboring gene predicted gene, 41694 Neighboring gene RIKEN cDNA 4930471G03 gene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ARF guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    PH and SEC7 domain-containing protein 2
    Names
    exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C
    exchange factor for ARF6 C
    pleckstrin homology and SEC7 domain-containing protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289602.1NP_001276531.1  PH and SEC7 domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001276531.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      BC065053, BC066026, BC066036
      Consensus CDS
      CCDS79612.1
      UniProtKB/Swiss-Prot
      Q6P1I6
      Related
      ENSMUSP00000135431.1, OTTMUSP00000061440, ENSMUST00000177432.7, OTTMUST00000110209
      Conserved Domains (3) summary
      cd00171
      Location:294461
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:507627
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:510619
      PH; PH domain
    2. NM_028707.4NP_082983.3  PH and SEC7 domain-containing protein 2

      See identical proteins and their annotated locations for NP_082983.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC066026, BC066036
      Consensus CDS
      CCDS37767.1
      UniProtKB/Swiss-Prot
      Q6P1I6
      Related
      ENSMUSP00000111381.2, OTTMUSP00000061438, ENSMUST00000115716.8, OTTMUST00000110207
      Conserved Domains (3) summary
      cd00171
      Location:294461
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:507630
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:527622
      PH; PH domain

    RNA

    1. NR_110349.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK045529, AK053835, BC066026, BC066036
      Related
      ENSMUST00000176472.7, OTTMUST00000110210

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      35964506..36014715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247011.2XP_011245313.1  PH and SEC7 domain-containing protein 2 isoform X2

      Conserved Domains (1) summary
      cd00171
      Location:294420
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    2. XM_006526297.3XP_006526360.1  PH and SEC7 domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      cd00171
      Location:294420
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
    3. XM_017317995.1XP_017173484.1  PH and SEC7 domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6P1I6
      Conserved Domains (3) summary
      cd00171
      Location:294462
      Sec7; Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor ...
      cd13295
      Location:508631
      PH_EFA6; Exchange Factor for ARF6 Pleckstrin homology (PH) domain
      pfam00169
      Location:528623
      PH; PH domain

    RNA

    1. XR_001782394.1 RNA Sequence

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