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    Tmem129 transmembrane protein 129 [ Mus musculus (house mouse) ]

    Gene ID: 68366, updated on 13-Mar-2018
    Official Symbol
    Tmem129provided by MGI
    Official Full Name
    transmembrane protein 129provided by MGI
    Primary source
    MGI:MGI:1915616
    See related
    Ensembl:ENSMUSG00000019295 Vega:OTTMUSG00000025080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA409575; 0610039G24Rik; 2410015J15Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 29.9), ovary adult (RPKM 25.9) and 28 other tissues See more
    Orthologs
    Location:
    5; 5 B2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (33653216..33657911, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (33995865..34000481, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40279 Neighboring gene stem-loop binding protein Neighboring gene transforming, acidic coiled-coil containing protein 3 Neighboring gene fibroblast growth factor receptor 3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase TM129
    Names
    RING-type E3 ubiquitin transferase TM129
    NP_080974.2
    XP_006504143.1
    XP_006504144.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356983.1NP_001343912.1  E3 ubiquitin-protein ligase TM129 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC162898
      Conserved Domains (1) summary
      pfam10272
      Location:1288
      Tmpp129; Putative transmembrane protein precursor
    2. NM_001356985.1NP_001343914.1  E3 ubiquitin-protein ligase TM129 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC162898
      Conserved Domains (1) summary
      pfam10272
      Location:1288
      Tmpp129; Putative transmembrane protein precursor
    3. NM_026698.3NP_080974.2  E3 ubiquitin-protein ligase TM129 isoform a

      See identical proteins and their annotated locations for NP_080974.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC162898, AK002836, BY275213
      Consensus CDS
      CCDS19206.1
      UniProtKB/Swiss-Prot
      Q8K304
      Related
      ENSMUSP00000019439.7, OTTMUSP00000030316, ENSMUST00000019439.8
      Conserved Domains (1) summary
      pfam10272
      Location:17359
      Tmpp129; Putative transmembrane protein precursor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      33653216..33657911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504080.1XP_006504143.1  E3 ubiquitin-protein ligase TM129 isoform X1

      UniProtKB/Swiss-Prot
      Q8K304
      Conserved Domains (1) summary
      pfam10272
      Location:1288
      Tmpp129; Putative transmembrane protein precursor
    2. XM_006504081.1XP_006504144.1  E3 ubiquitin-protein ligase TM129 isoform X1

      UniProtKB/Swiss-Prot
      Q8K304
      Conserved Domains (1) summary
      pfam10272
      Location:1288
      Tmpp129; Putative transmembrane protein precursor
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