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    BDKRB2 bradykinin receptor B2 [ Homo sapiens (human) ]

    Gene ID: 624, updated on 8-Apr-2018
    Official Symbol
    BDKRB2provided by HGNC
    Official Full Name
    bradykinin receptor B2provided by HGNC
    Primary source
    HGNC:HGNC:1030
    See related
    Ensembl:ENSG00000168398 MIM:113503; Vega:OTTHUMG00000171408
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B2R; BK2; BK-2; BKR2; BRB2
    Summary
    This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in urinary bladder (RPKM 13.5), gall bladder (RPKM 13.3) and 16 other tissues See more
    Orthologs
    Location:
    14q32.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (96204798..96244329)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96671016..96710666)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene TCL1 upstream neural differentiation-associated RNA Neighboring gene chromosome 14 open reading frame 132 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 1 Neighboring gene bradykinin receptor B1 Neighboring gene autophagy related 2B

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of bradykinin receptor B2 (BDKRB2) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: BDKRB1

    Homology

    Clone Names

    • DKFZp686O088

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    bradykinin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol phospholipase C activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    type 1 angiotensin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    B2 bradykinin receptor
    Names
    BK-2 receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000623.3NP_000614.1  B2 bradykinin receptor

      See identical proteins and their annotated locations for NP_000614.1

      Status: REVIEWED

      Source sequence(s)
      AL355102, DA096163, DC422332
      Consensus CDS
      CCDS9942.1
      UniProtKB/Swiss-Prot
      P30411
      Related
      ENSP00000450482.1, OTTHUMP00000245971, ENST00000554311.1, OTTHUMT00000413294
      Conserved Domains (1) summary
      pfam00001
      Location:74332
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      96204798..96244329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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