Atp11a ATPase, class VI, type 11A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp11aprovided by MGI
Official Full Name: ATPase, class VI, type 11Aprovided by MGI
Primary source: MGI:MGI:1354735
See related: Ensembl:ENSMUSG00000031441 Vega:OTTMUSG00000020604
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ih; Atpc1h; AU040868; 4930558F19Rik
Expression: Broad expression in lung adult (RPKM 80.2), kidney adult (RPKM 45.0) and 21 other tissues See more
Orthologs: human all

Genomic context

See Atp11a in Genome Data Viewer Map Viewer

Location:: 8; 8 A1.1

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	8	NC_000074.6 (12757016..12868728)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	8	NC_000074.5 (12757016..12868728)

Chromosome 8 - NC_000074.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

results show that elevated levels of ATP11a can protect malignant lymphoblastic leukemia cells against several novel small molecule signal transduction inhibitors
Title: Resistance to farnesyltransferase inhibitors in Bcr/Abl-positive lymphoblastic leukemia by increased expression of a novel ABC transporter homolog ATP11a.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Pathways from BioSystems

Go to the top of the page Help

Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lung fibrosis, organism-specific biosystem (from WikiPathways)
Lung fibrosis, organism-specific biosystem(Nanoparticle) induced lung fibrosis pathway. Under construction. Note! Mouse homologues for SERPINA1 and SFTPA2 are missing and the pathway currently contains the human equivalents. Other users are ...
Neutrophil degranulation, organism-specific biosystem (from REACTOME)
Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Go to the top of the page Help

Markers

BE136256 (e-PCR)
- UniSTS:208242

Atp11a (e-PCR), detects polymorphism
- UniSTS:527257

AW146001 (e-PCR)
- UniSTS:179706

Homology

Homologs of the Atp11a gene: The Atp11a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 196 organisms have orthologs with human gene Atp11a
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
magnesium ion binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
phospholipid-translocating ATPase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
lipid transport	IEA Inferred from Electronic Annotation more info
phospholipid translocation	IBA Inferred from Biological aspect of Ancestor more info
phospholipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
endosome	IEA Inferred from Electronic Annotation more info
integral component of membrane	IEA Inferred from Electronic Annotation more info
intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: probable phospholipid-transporting ATPase IH

Names: 9130422H11Rik; ATPase 11A, class VI; ATPase 11A, p type; ATPase, class 1, member h; P4-ATPase flippase complex alpha subunit ATP11A

NP_001280596.1

EC 3.6.3.1

NP_001280597.1

EC 3.6.3.1

NP_056619.1

EC 3.6.3.1

XP_006508897.1

EC 3.6.3.1

XP_006508900.1

EC 3.6.3.1

XP_006508902.1

EC 3.6.3.1

XP_006508903.1

EC 3.6.3.1

XP_011240369.1

EC 3.6.3.1

XP_011240370.1

EC 3.6.3.1

XP_011240371.1

EC 3.6.3.1

XP_017168382.1

EC 3.6.3.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293667.1 → NP_001280596.1 probable phospholipid-transporting ATPase IH isoform 2

See identical proteins and their annotated locations for NP_001280596.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC134581, AK147497

Consensus CDS

CCDS80858.1

UniProtKB/TrEMBL

E9Q3G7

Related

ENSMUSP00000033818.3, OTTMUSP00000022482, ENSMUST00000033818.9, OTTMUST00000048808

Conserved Domains (7) summary

TIGR01652
Location:45 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1106

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_001293668.1 → NP_001280597.1 probable phospholipid-transporting ATPase IH isoform 3

See identical proteins and their annotated locations for NP_001280597.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC134581, AK147497, BC145399

Conserved Domains (7) summary

TIGR01652
Location:45 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1106

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases
NM_015804.3 → NP_056619.1 probable phospholipid-transporting ATPase IH isoform 1

See identical proteins and their annotated locations for NP_056619.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC134581, AK147497, CF167530

Consensus CDS

CCDS40223.1

UniProtKB/Swiss-Prot

P98197

Related

ENSMUSP00000088779.5, OTTMUSP00000022483, ENSMUST00000091237.11, OTTMUST00000048809

Conserved Domains (7) summary

TIGR01652
Location:45 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1106

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases

RNA

NR_121603.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC134581, AK147497, BC145400

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

NC_000074.6 Reference GRCm38.p4 C57BL/6J

Range

12757016..12868728

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242069.2 → XP_011240371.1 probable phospholipid-transporting ATPase IH isoform X3

See identical proteins and their annotated locations for XP_011240371.1

Conserved Domains (7) summary

TIGR01652
Location:45 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1106

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases
XM_011242068.1 → XP_011240370.1 probable phospholipid-transporting ATPase IH isoform X4

See identical proteins and their annotated locations for XP_011240370.1

UniProtKB/Swiss-Prot

P98197

Conserved Domains (7) summary

TIGR01652
Location:45 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1106

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases
XM_006508837.3 → XP_006508900.1 probable phospholipid-transporting ATPase IH isoform X2

Conserved Domains (7) summary

TIGR01652
Location:45 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1106

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases
XM_006508834.3 → XP_006508897.1 probable phospholipid-transporting ATPase IH isoform X1

See identical proteins and their annotated locations for XP_006508897.1

UniProtKB/TrEMBL

E9Q3G7

Conserved Domains (7) summary

TIGR01652
Location:45 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1106

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases
XM_011242067.1 → XP_011240369.1 probable phospholipid-transporting ATPase IH isoform X1

See identical proteins and their annotated locations for XP_011240369.1

UniProtKB/TrEMBL

E9Q3G7

Conserved Domains (7) summary

TIGR01652
Location:45 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1106

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases
XM_017312893.1 → XP_017168382.1 probable phospholipid-transporting ATPase IH isoform X3

Conserved Domains (7) summary

TIGR01652
Location:45 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1106

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases
XM_006508839.3 → XP_006508902.1 probable phospholipid-transporting ATPase IH isoform X3

See identical proteins and their annotated locations for XP_006508902.1

Conserved Domains (7) summary

TIGR01652
Location:45 → 1106

ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1106

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases
XM_006508840.2 → XP_006508903.1 probable phospholipid-transporting ATPase IH isoform X5

Conserved Domains (7) summary

TIGR01494
Location:94 → 903

ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC

pfam00122
Location:102 → 187

E1-E2_ATPase; E1-E2 ATPase

pfam13246
Location:477 → 587

Cation_ATPase; Cation transport ATPase (P-type)

pfam16209
Location:42 → 95

PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal

pfam16212
Location:854 → 1030

PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal

cl00297
Location:641 → 697

R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...

cl21460
Location:809 → 852

HAD_like; Haloacid Dehalogenase-like Hydrolases