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    Atp11a ATPase, class VI, type 11A [ Mus musculus (house mouse) ]

    Gene ID: 50770, updated on 20-Mar-2018
    Official Symbol
    Atp11aprovided by MGI
    Official Full Name
    ATPase, class VI, type 11Aprovided by MGI
    Primary source
    MGI:MGI:1354735
    See related
    Ensembl:ENSMUSG00000031441 Vega:OTTMUSG00000020604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ih; Atpc1h; AU040868; 4930558F19Rik
    Expression
    Broad expression in lung adult (RPKM 80.2), kidney adult (RPKM 45.0) and 21 other tissues See more
    Orthologs
    Location:
    8; 8 A1.1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (12757016..12868728)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (12757016..12868728)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39133 Neighboring gene predicted gene, 33587 Neighboring gene predicted gene 15350 Neighboring gene uncharacterized LOC105243125 Neighboring gene predicted gene, 33637 Neighboring gene mcf.2 transforming sequence-like

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid-translocating ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    recycling endosome ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    probable phospholipid-transporting ATPase IH
    Names
    9130422H11Rik
    ATPase 11A, class VI
    ATPase 11A, p type
    ATPase, class 1, member h
    P4-ATPase flippase complex alpha subunit ATP11A
    NP_001280596.1
    NP_001280597.1
    NP_056619.1
    XP_006508897.1
    XP_006508900.1
    XP_006508902.1
    XP_006508903.1
    XP_011240369.1
    XP_011240370.1
    XP_011240371.1
    XP_017168382.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293667.1NP_001280596.1  probable phospholipid-transporting ATPase IH isoform 2

      See identical proteins and their annotated locations for NP_001280596.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC134581, AK147497
      Consensus CDS
      CCDS80858.1
      UniProtKB/TrEMBL
      E9Q3G7
      Related
      ENSMUSP00000033818.3, OTTMUSP00000022482, ENSMUST00000033818.9, OTTMUST00000048808
      Conserved Domains (7) summary
      TIGR01652
      Location:451106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    2. NM_001293668.1NP_001280597.1  probable phospholipid-transporting ATPase IH isoform 3

      See identical proteins and their annotated locations for NP_001280597.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 3' end compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC134581, AK147497, BC145399
      Conserved Domains (7) summary
      TIGR01652
      Location:451106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    3. NM_015804.3NP_056619.1  probable phospholipid-transporting ATPase IH isoform 1

      See identical proteins and their annotated locations for NP_056619.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC134581, AK147497, CF167530
      Consensus CDS
      CCDS40223.1
      UniProtKB/Swiss-Prot
      P98197
      Related
      ENSMUSP00000088779.5, OTTMUSP00000022483, ENSMUST00000091237.11, OTTMUST00000048809
      Conserved Domains (7) summary
      TIGR01652
      Location:451106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RNA

    1. NR_121603.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC134581, AK147497, BC145400

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      12757016..12868728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242069.2XP_011240371.1  probable phospholipid-transporting ATPase IH isoform X3

      See identical proteins and their annotated locations for XP_011240371.1

      Conserved Domains (7) summary
      TIGR01652
      Location:451106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    2. XM_011242068.1XP_011240370.1  probable phospholipid-transporting ATPase IH isoform X4

      See identical proteins and their annotated locations for XP_011240370.1

      UniProtKB/Swiss-Prot
      P98197
      Conserved Domains (7) summary
      TIGR01652
      Location:451106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    3. XM_006508837.3XP_006508900.1  probable phospholipid-transporting ATPase IH isoform X2

      Conserved Domains (7) summary
      TIGR01652
      Location:451106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    4. XM_006508834.3XP_006508897.1  probable phospholipid-transporting ATPase IH isoform X1

      See identical proteins and their annotated locations for XP_006508897.1

      UniProtKB/TrEMBL
      E9Q3G7
      Conserved Domains (7) summary
      TIGR01652
      Location:451106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    5. XM_011242067.1XP_011240369.1  probable phospholipid-transporting ATPase IH isoform X1

      See identical proteins and their annotated locations for XP_011240369.1

      UniProtKB/TrEMBL
      E9Q3G7
      Conserved Domains (7) summary
      TIGR01652
      Location:451106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    6. XM_017312893.1XP_017168382.1  probable phospholipid-transporting ATPase IH isoform X3

      Conserved Domains (7) summary
      TIGR01652
      Location:451106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    7. XM_006508839.3XP_006508902.1  probable phospholipid-transporting ATPase IH isoform X3

      See identical proteins and their annotated locations for XP_006508902.1

      Conserved Domains (7) summary
      TIGR01652
      Location:451106
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541106
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    8. XM_006508840.2XP_006508903.1  probable phospholipid-transporting ATPase IH isoform X5

      Conserved Domains (7) summary
      TIGR01494
      Location:94903
      ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC
      pfam00122
      Location:102187
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:477587
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:4295
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:8541030
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl00297
      Location:641697
      R3H; R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich ...
      cl21460
      Location:809852
      HAD_like; Haloacid Dehalogenase-like Hydrolases
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