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    ENO4 enolase 4 [ Homo sapiens (human) ]

    Gene ID: 387712, updated on 29-Mar-2018
    Official Symbol
    ENO4provided by HGNC
    Official Full Name
    enolase 4provided by HGNC
    Primary source
    HGNC:HGNC:31670
    See related
    Ensembl:ENSG00000188316 MIM:131375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf134
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    See ENO4 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (116848230..116911803)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118608741..118642112)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 12A Neighboring gene uncharacterized LOC105378498 Neighboring gene Sharpr-MPRA regulatory region 690 Neighboring gene shootin 1 Neighboring gene VISTA enhancer hs841 Neighboring gene ventral anterior homeobox 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Markers

    Homology

    Clone Names

    • AC023283.3

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    phosphopyruvate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    enolase 4
    Names
    2-phospho-D-glycerate hydro-lyase
    enolase family member 4
    enolase-like protein ENO4
    NP_001229628.1
    XP_005269872.1
    XP_006717898.1
    XP_011538099.1
    XP_011538101.1
    XP_016871730.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242699.1NP_001229628.1  enolase 4

      Status: VALIDATED

      Source sequence(s)
      AC023283
      Consensus CDS
      CCDS73206.1
      UniProtKB/TrEMBL
      J3KNX1
      Related
      ENSP00000345555.6, ENST00000341276.9
      Conserved Domains (2) summary
      TIGR01060
      Location:68568
      eno; phosphopyruvate hydratase
      cl21457
      Location:70567
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

      Range
      116848230..116911803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717835.3XP_006717898.1  enolase 4 isoform X1

      Conserved Domains (2) summary
      TIGR01060
      Location:68568
      eno; phosphopyruvate hydratase
      cl21457
      Location:70567
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
    2. XM_011539797.3XP_011538099.1  enolase 4 isoform X2

      Conserved Domains (2) summary
      TIGR01060
      Location:68526
      eno; phosphopyruvate hydratase
      cl21457
      Location:70525
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
    3. XM_017016241.2XP_016871730.1  enolase 4 isoform X3

    4. XM_011539799.3XP_011538101.1  enolase 4 isoform X4

      Conserved Domains (1) summary
      cl21457
      Location:70404
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...
    5. XM_005269815.3XP_005269872.1  enolase 4 isoform X5

      Conserved Domains (1) summary
      cl21457
      Location:70404
      TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

    RNA

    1. XR_001747107.1 RNA Sequence

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