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    CA13 carbonic anhydrase 13 [ Homo sapiens (human) ]

    Gene ID: 377677, updated on 29-Mar-2018
    Official Symbol
    CA13provided by HGNC
    Official Full Name
    carbonic anhydrase 13provided by HGNC
    Primary source
    HGNC:HGNC:14914
    See related
    Ensembl:ENSG00000185015 MIM:611436; Vega:OTTHUMG00000164940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAXIII
    Summary
    Carbonic anhydrases (CAs) are a family of zinc metalloenzymes. For background information on the CA family, see MIM 114800.[supplied by OMIM, Mar 2008]
    Expression
    Broad expression in small intestine (RPKM 7.8), duodenum (RPKM 6.3) and 18 other tissues See more
    Orthologs
    Location:
    8q21.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (85245487..85284073)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (86157716..86196302)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 5 Neighboring gene uncharacterized LOC105375936 Neighboring gene chromosome 8 open reading frame 59 Neighboring gene uncharacterized LOC105375935 Neighboring gene carbonic anhydrase 1 Neighboring gene CA1 upstream erythroid promoter Neighboring gene CA3 antisense RNA 1 Neighboring gene carbonic anhydrase 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
    NHGRI GWA Catalog
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Nitrogen metabolism, organism-specific biosystem (from KEGG)
      Nitrogen metabolism, organism-specific biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
    • Nitrogen metabolism, conserved biosystem (from KEGG)
      Nitrogen metabolism, conserved biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
    • Reversible hydration of carbon dioxide, organism-specific biosystem (from REACTOME)
      Reversible hydration of carbon dioxide, organism-specific biosystemCarbonic anhydrases reversibly catalyze the hydration of carbon dioxide and directly produce bicarbonate and protons, bypassing the formation of carbonic acid (reviewed in Lindskog 1997, Breton 2001,...

    Markers

    Potential readthrough

    Included gene: CA3

    Homology

    Clone Names

    • FLJ36434, FLJ37995, MGC59868

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbonate dehydratase activity TAS
    Traceable Author Statement
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    bicarbonate transport TAS
    Traceable Author Statement
    more info
     
    one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    carbonic anhydrase 13
    Names
    CA-XIII
    carbonate dehydratase XIII
    carbonic anhydrase XIII
    NP_940986.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198584.2NP_940986.1  carbonic anhydrase 13

      See identical proteins and their annotated locations for NP_940986.1

      Status: VALIDATED

      Source sequence(s)
      AK095314, BC052602, DB287770
      Consensus CDS
      CCDS6236.1
      UniProtKB/Swiss-Prot
      Q8N1Q1
      Related
      ENSP00000318912.3, OTTHUMP00000227972, ENST00000321764.3, OTTHUMT00000381066
      Conserved Domains (1) summary
      cd03119
      Location:2261
      alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

      Range
      85245487..85284073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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