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    DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 [ Homo sapiens (human) ]

    Gene ID: 25822, updated on 8-Apr-2018
    Official Symbol
    DNAJB5provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B5provided by HGNC
    Primary source
    HGNC:HGNC:14887
    See related
    Ensembl:ENSG00000137094 MIM:611328; Vega:OTTHUMG00000019840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Hsc40
    Summary
    This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017]
    Expression
    Broad expression in heart (RPKM 17.5), brain (RPKM 13.1) and 21 other tissues See more
    Orthologs
    Location:
    9p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (34989641..34998433)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34989638..34998430)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene PHD finger protein 24 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta pseudogene 6 Neighboring gene DNAJB5 divergent transcript Neighboring gene SPATA31 subfamily D member 1 pseudogene Neighboring gene SYF2 pre-mRNA splicing factor pseudogene 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    response to unfolded protein IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    dnaJ homolog subfamily B member 5
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 5
    heat shock cognate 40
    heat shock protein Hsp40-2
    heat shock protein Hsp40-3
    heat shock protein cognate 40

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053054.1 RefSeqGene

      Range
      5273..14065
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135004.2NP_001128476.2  dnaJ homolog subfamily B member 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AA434108, AF087870, AF088982, AK023253, AL355377
      Consensus CDS
      CCDS47960.2
      UniProtKB/Swiss-Prot
      O75953
      Related
      ENSP00000404079.3, OTTHUMP00000021308, ENST00000453597.7, OTTHUMT00000052249
      Conserved Domains (3) summary
      cd10747
      Location:283447
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
      COG0484
      Location:114457
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:118179
      DnaJ; DnaJ domain
    2. NM_001135005.2NP_001128477.1  dnaJ homolog subfamily B member 5 isoform 1

      See identical proteins and their annotated locations for NP_001128477.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate translation initiation codon, compared to variant 2. The encoded isoform (1) has a shorter and distinct C-terminus compared to isoform 2. Both variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AA434108, AK023253, AK299647, AL355377
      Consensus CDS
      CCDS47959.1
      UniProtKB/Swiss-Prot
      O75953
      Related
      ENSP00000413684.2, OTTHUMP00000021307, ENST00000454002.6, OTTHUMT00000052248
      Conserved Domains (1) summary
      COG0484
      Location:72415
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    3. NM_001349723.1NP_001336652.1  dnaJ homolog subfamily B member 5 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate translation initiation codon, compared to variant 2. The encoded isoform (1) has a shorter and distinct C-terminus compared to isoform 2. Both variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AI122943, AL355377
      Conserved Domains (1) summary
      COG0484
      Location:72415
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    4. NM_001349724.1NP_001336653.1  dnaJ homolog subfamily B member 5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses an alternate translation initiation codon, compared to variant 2. The encoded isoform (3) has a shorter N-terminus, compared to isoform 2. Both variants 3 and 5 encode the same isoform (3).
      Source sequence(s)
      AI122943, AL355377
      Related
      ENSP00000441999.1, ENST00000545841.5
      Conserved Domains (1) summary
      COG0484
      Location:1343
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    5. NM_001349725.1NP_001336654.1  dnaJ homolog subfamily B member 5 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site in the 5' coding region, compared to variant 2. The encoded isoform (4) is shorter than isoform 2.
      Source sequence(s)
      AI122943, AL355377
      Conserved Domains (2) summary
      COG0484
      Location:113456
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      cl26852
      Location:46166
      HSCB_C; HSCB C-terminal oligomerization domain
    6. NM_012266.5NP_036398.3  dnaJ homolog subfamily B member 5 isoform 3

      See identical proteins and their annotated locations for NP_036398.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation initiation codon, compared to variant 2. The encoded isoform (3) has a shorter N-terminus, compared to isoform 2. Both variants 3 and 5 encode the same isoform (3).
      Source sequence(s)
      AA434108, AK023253, AK314671, AL355377
      Consensus CDS
      CCDS35007.1
      UniProtKB/Swiss-Prot
      O75953
      Related
      ENSP00000312517.5, OTTHUMP00000021309, ENST00000312316.9, OTTHUMT00000052250
      Conserved Domains (1) summary
      COG0484
      Location:1343
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

      Range
      34989641..34998433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005251428.3XP_005251485.1  dnaJ homolog subfamily B member 5 isoform X1

      See identical proteins and their annotated locations for XP_005251485.1

      UniProtKB/Swiss-Prot
      O75953
      Conserved Domains (1) summary
      COG0484
      Location:1343
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
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