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    Abce1 ATP-binding cassette, sub-family E (OABP), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 24015, updated on 4-Feb-2018
    Official Symbol
    Abce1provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family E (OABP), member 1provided by MGI
    Primary source
    MGI:MGI:1195458
    See related
    Ensembl:ENSMUSG00000058355 Vega:OTTMUSG00000061313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RLI; Oabp; RNS41; RNS4I; C79080; Rnaseli
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in liver E14 (RPKM 27.7), CNS E11.5 (RPKM 26.2) and 24 other tissues See more
    Orthologs
    Location:
    8; 8 C1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (79683442..79711740, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (82207341..82235639, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene OTU domain containing 4 Neighboring gene tumor protein D52, pseudogene Neighboring gene anaphase promoting complex subunit 10 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 30494

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Gene trapped (1) 
    • Targeted (3) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    endoribonuclease inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    negative regulation of endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    COLOCALIZES_WITH eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ATP-binding cassette sub-family E member 1
    Names
    ATP-binding cassette, subfamily E, member 1
    RNS4l (Eye)
    RNase L inhibitor
    ribonuclease 4 inhibitor
    ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) inhibitor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015751.2NP_056566.2  ATP-binding cassette sub-family E member 1

      See identical proteins and their annotated locations for NP_056566.2

      Status: VALIDATED

      Source sequence(s)
      AK167370, AV213051, BB651928, CD564438
      Consensus CDS
      CCDS22438.1
      UniProtKB/Swiss-Prot
      P61222
      UniProtKB/TrEMBL
      Q3TJM9, Q3UHY8
      Related
      ENSMUSP00000079379.6, OTTMUSP00000077617, ENSMUST00000080536.7, OTTMUST00000149630
      Conserved Domains (1) summary
      COG1245
      Location:4597
      Rli1; Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_152614.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC101687, AC158348

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      79683442..79711740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_878809.2 RNA Sequence

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