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    TOGARAM1 TOG array regulator of axonemal microtubules 1 [ Homo sapiens (human) ]

    Gene ID: 23116, updated on 8-Apr-2018
    Official Symbol
    TOGARAM1provided by HGNC
    Official Full Name
    TOG array regulator of axonemal microtubules 1provided by HGNC
    Primary source
    HGNC:HGNC:19959
    See related
    Ensembl:ENSG00000198718 MIM:617618; Vega:OTTHUMG00000140264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM179B; KIAA0423
    Expression
    Ubiquitous expression in thyroid (RPKM 6.9), brain (RPKM 6.9) and 25 other tissues See more
    Orthologs
    Location:
    14q21.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (44962190..45074431)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (45431416..45543634)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927418 Neighboring gene chromosome 14 open reading frame 28 Neighboring gene kelch like family member 28 Neighboring gene uncharacterized LOC105370474 Neighboring gene pre-mRNA processing factor 39 Neighboring gene small nucleolar RNA, C/D box 127

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0423, DKFZp686D12126

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    axoneme assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    non-motile cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of microtubule polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    TOG array regulator of axonemal microtubules protein 1
    Names
    crescerin
    crescerin-1
    family with sequence similarity 179 member B
    protein FAM179B

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308120.1NP_001295049.1  TOG array regulator of axonemal microtubules protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001295049.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA911186, AK295185, BC065234, BX648723
      Consensus CDS
      CCDS76676.1
      UniProtKB/TrEMBL
      B4DHM7, G3XAE9, Q6P183
      Related
      ENSP00000354917.2, OTTHUMP00000178915, ENST00000361462.6, OTTHUMT00000276792
      Conserved Domains (2) summary
      pfam15741
      Location:8111152
      LRIF1; Ligand-dependent nuclear receptor-interacting factor 1
      sd00044
      Location:395423
      HEAT; HEAT repeat [structural motif]
    2. NM_015091.3NP_055906.2  TOG array regulator of axonemal microtubules protein 1 isoform 2

      See identical proteins and their annotated locations for NP_055906.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AB007883, AK295185, AL049870, BC065234
      Consensus CDS
      CCDS9681.1
      UniProtKB/Swiss-Prot
      Q9Y4F4
      UniProtKB/TrEMBL
      B4DHM7, Q6P183
      Related
      ENSP00000355045.3, OTTHUMP00000178914, ENST00000361577.7, OTTHUMT00000276791
      Conserved Domains (2) summary
      pfam15741
      Location:8111152
      LRIF1; Ligand-dependent nuclear receptor-interacting factor 1
      sd00044
      Location:395423
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_131765.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon and contains an additional alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK295185, AL049870, BC057255, BC065234, CR749557

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

      Range
      44962190..45074431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536571.1XP_011534873.1  TOG array regulator of axonemal microtubules protein 1 isoform X3

      Conserved Domains (2) summary
      pfam15741
      Location:8111152
      LRIF1; Ligand-dependent nuclear receptor-interacting factor 1
      sd00044
      Location:395423
      HEAT; HEAT repeat [structural motif]
    2. XM_017021099.1XP_016876588.1  TOG array regulator of axonemal microtubules protein 1 isoform X2

    3. XM_017021098.1XP_016876587.1  TOG array regulator of axonemal microtubules protein 1 isoform X1

    4. XM_017021100.1XP_016876589.1  TOG array regulator of axonemal microtubules protein 1 isoform X4

      UniProtKB/Swiss-Prot
      Q9Y4F4
      Related
      ENSP00000451829.1, OTTHUMP00000244450, ENST00000557423.5, OTTHUMT00000410452

    RNA

    1. XR_001750194.1 RNA Sequence

    2. XR_001750195.1 RNA Sequence

    3. XR_943403.2 RNA Sequence

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