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    Gba2 glucosidase beta 2 [ Mus musculus (house mouse) ]

    Gene ID: 230101, updated on 4-Feb-2018
    Official Symbol
    Gba2provided by MGI
    Official Full Name
    glucosidase beta 2provided by MGI
    Primary source
    MGI:MGI:2654325
    See related
    Ensembl:ENSMUSG00000028467 Vega:OTTMUSG00000006971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F630034E04
    Expression
    Ubiquitous expression in testis adult (RPKM 29.8), whole brain E14.5 (RPKM 28.2) and 28 other tissues See more
    Orthologs
    Location:
    4; 4 A5
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (43566928..43578864, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (43579800..43591736, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 9 Neighboring gene tropomyosin 2, beta Neighboring gene talin 1 Neighboring gene cAMP responsive element binding protein 3 Neighboring gene predicted gene, 42278 Neighboring gene RAB6A GEF compex partner 1 Neighboring gene microseminoprotein, prostate associated Neighboring gene predicted gene, 42279

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    beta-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    beta-glucosidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    glucosylceramidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    bile acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    central nervous system neuron development ISO
    Inferred from Sequence Orthology
    more info
     
    glucosylceramide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glycoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glycoside catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    non-lysosomal glucosylceramidase
    Names
    NLGase
    beta-glucocerebrosidase 2
    beta-glucosidase 2
    bile acid
    glucosidase, beta (bile acid) 2
    glucosylceramidase 2
    NP_766280.2
    XP_006537895.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172692.3NP_766280.2  non-lysosomal glucosylceramidase

      See identical proteins and their annotated locations for NP_766280.2

      Status: VALIDATED

      Source sequence(s)
      AK158174, BB869336, BC056935
      Consensus CDS
      CCDS18103.1
      UniProtKB/Swiss-Prot
      Q69ZF3
      Related
      ENSMUSP00000030189.7, OTTMUSP00000007403, ENSMUST00000030189.13, OTTMUST00000016147
      Conserved Domains (3) summary
      pfam04685
      Location:512875
      DUF608; Protein of unknown function, DUF608
      pfam06202
      Location:610738
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam12215
      Location:157446
      GBA2_N; beta-Glucocerebrosidase 2 N terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      43566928..43578864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537832.3XP_006537895.1  non-lysosomal glucosylceramidase isoform X1

      Conserved Domains (3) summary
      pfam04685
      Location:323686
      DUF608; Protein of unknown function, DUF608
      pfam06202
      Location:421549
      GDE_C; Amylo-alpha-1,6-glucosidase
      pfam12215
      Location:66257
      GBA2_N; beta-Glucocerebrosidase 2 N terminal
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