Sfrp1 secreted frizzled-related protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sfrp1provided by MGI
Official Full Name: secreted frizzled-related protein 1provided by MGI
Primary source: MGI:MGI:892014
See related: Ensembl:ENSMUSG00000031548 Vega:OTTMUSG00000021102
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sFRP-1; AW011917; AW107218; AW742929; 2210415K03Rik
Expression: Ubiquitous expression in kidney adult (RPKM 23.7), CNS E11.5 (RPKM 22.8) and 26 other tissues See more
Orthologs: human all

Genomic context

See Sfrp1 in Genome Data Viewer Map Viewer

Location:: 8 A2; 8 11.48 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCm38.p4 (GCF_000001635.24)	8	NC_000074.6 (23411382..23449632)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	8	NC_000074.5 (24521974..24560104)

Chromosome 8 - NC_000074.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Loss of SFRP1 likely contributes to tumor progression by altering the expression of a critical transcription factor in both the epithelium and the immune system.
Title: Regulation of early growth response 2 expression by secreted frizzled related protein 1.
OVOL1-regulated Fst and SFRP1 affect hair inductive potency of neonatal dermal cells.
Title: Follistatin and secreted frizzled-related protein 1, OVO homolog-like 1-regulated genes, are important for hair follicle neogenesis.
Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.
Title: Estrogen-mediated signaling is differentially affected by the expression levels of Sfrp1 in mammary epithelial cells.
Study suggests that the induction of the WNT pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.
Title: Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy.
the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity
Title: Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration.
findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease
Title: Maintenance of the bronchial alveolar stem cells in an undifferentiated state by secreted frizzled-related protein 1.
Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt/PCP pathway in a mouse model of obstructive nephropathy
Title: Secreted Frizzled-related protein 1 (Sfrp1) regulates the progression of renal fibrosis in a mouse model of obstructive nephropathy.
SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.
Title: The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1.
Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 expression is decreased, and that p53 expression is generally diminished.
Title: Tumour supressor secreted frizzled related protein 1 regulates p53-mediated apoptosis.
secreted FRP1 either inhibits or enhances signaling in the Wnt3a/beta-catenin pathway
Title: Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Chemically induced (ENU) (1) 1 citation

Pathways from BioSystems

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BMP Signaling Pathway in Eyelid Development, organism-specific biosystem (from WikiPathways)
BMP Signaling Pathway in Eyelid Development, organism-specific biosystemThe signaling pathways involved in eyelid development are displayed with interactions that are known (solid arrows) and proposed (dotted arrows). The four main pathways shown are activated by Fgf10 a...
Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW011917 (e-PCR)
- UniSTS:179715

AW107218 (e-PCR)
- UniSTS:179716

Sfrp1 (e-PCR), detects polymorphism
- UniSTS:527124

Sfrp1 (e-PCR), detects polymorphism
- UniSTS:471843

Sfrp1 (e-PCR), detects polymorphism
- UniSTS:507219

Sfrp1 (e-PCR), detects polymorphism
- UniSTS:498803

RH141094 (e-PCR)
- UniSTS:223092

AW742929 (e-PCR)
- UniSTS:208249

Sfrp1 (e-PCR), detects polymorphism
- UniSTS:527005

Sfrp1 (e-PCR), detects polymorphism
- UniSTS:527536

Sfrp1 (e-PCR), detects polymorphism
- UniSTS:525511

Homology

Homologs of the Sfrp1 gene: The Sfrp1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 194 organisms have orthologs with human gene Sfrp1
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
Wnt-activated receptor activity	IBA Inferred from Biological aspect of Ancestor more info
Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
Wnt-protein binding	ISO Inferred from Sequence Orthology more info	PubMed
cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
drug binding	ISO Inferred from Sequence Orthology more info
frizzled binding	ISO Inferred from Sequence Orthology more info
heparin binding	ISO Inferred from Sequence Orthology more info
identical protein binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
Wnt signaling pathway involved in somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
Wnt signaling pathway, planar cell polarity pathway	IDA Inferred from Direct Assay more info	PubMed
actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info	PubMed
anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
bone trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
cell differentiation	IEA Inferred from Electronic Annotation more info
cellular response to X-ray	IDA Inferred from Direct Assay more info	PubMed
cellular response to estrogen stimulus	IDA Inferred from Direct Assay more info	PubMed
cellular response to estrogen stimulus	ISO Inferred from Sequence Orthology more info
cellular response to fibroblast growth factor stimulus	ISO Inferred from Sequence Orthology more info
cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
cellular response to heparin	ISO Inferred from Sequence Orthology more info
cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
convergent extension involved in somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
development of primary male sexual characteristics	IGI Inferred from Genetic Interaction more info	PubMed
digestive tract morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
dopaminergic neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
dorsal/ventral axis specification	ISO Inferred from Sequence Orthology more info
female gonad development	IGI Inferred from Genetic Interaction more info	PubMed
hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
male gonad development	IGI Inferred from Genetic Interaction more info	PubMed
multicellular organism development	IEA Inferred from Electronic Annotation more info
negative regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
negative regulation of BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of JUN kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification	ISO Inferred from Sequence Orthology more info
negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of bone remodeling	ISO Inferred from Sequence Orthology more info
negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
negative regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of ossification	ISO Inferred from Sequence Orthology more info
negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of osteoblast proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
negative regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
negative regulation of planar cell polarity pathway involved in axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of transcription, DNA-templated	ISO Inferred from Sequence Orthology more info
neural crest cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
neural tube development	IGI Inferred from Genetic Interaction more info	PubMed
non-canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
planar cell polarity pathway involved in neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info	PubMed
positive regulation of fibroblast apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-templated	ISO Inferred from Sequence Orthology more info
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of branching involved in prostate gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell cycle process	ISO Inferred from Sequence Orthology more info
regulation of establishment of planar polarity	IGI Inferred from Genetic Interaction more info	PubMed
regulation of midbrain dopaminergic neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
regulation of ossification	ISO Inferred from Sequence Orthology more info
response to drug	IDA Inferred from Direct Assay more info	PubMed
response to drug	ISO Inferred from Sequence Orthology more info
response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
somitogenesis	IEP Inferred from Expression Pattern more info	PubMed
somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
stromal-epithelial cell signaling involved in prostate gland development	IEP Inferred from Expression Pattern more info	PubMed
substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info	PubMed
ureteric bud development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
cell surface	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
extracellular matrix	ISO Inferred from Sequence Orthology more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	HDA more info	PubMed
extracellular space	IBA Inferred from Biological aspect of Ancestor more info
extracellular space	ISO Inferred from Sequence Orthology more info
integral component of membrane	IBA Inferred from Biological aspect of Ancestor more info
intracellular	ISO Inferred from Sequence Orthology more info
plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: secreted frizzled-related protein 1

Names: secreted frizzled-related sequence protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013834.3 → NP_038862.2 secreted frizzled-related protein 1 precursor

See identical proteins and their annotated locations for NP_038862.2

Status: VALIDATED

Source sequence(s)

AK081052, BB620977, BC094662

Consensus CDS

CCDS22191.1

UniProtKB/Swiss-Prot

Q8C4U3

Related

ENSMUSP00000033952.7, OTTMUSP00000023228, ENSMUST00000033952.7, OTTMUST00000049933

Conserved Domains (2) summary

cd07443
Location:52 → 175

CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity

cd03580
Location:183 → 306

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

NC_000074.6 Reference GRCm38.p4 C57BL/6J

Range

23411382..23449632

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242128.1 → XP_011240430.1 secreted frizzled-related protein 1 isoform X1

See identical proteins and their annotated locations for XP_011240430.1

UniProtKB/Swiss-Prot

Q8C4U3

Conserved Domains (2) summary

cd07443
Location:52 → 175

CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity

cd03580
Location:183 → 306

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...