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    Sfrp1 secreted frizzled-related protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 20377, updated on 24-Apr-2018
    Official Symbol
    Sfrp1provided by MGI
    Official Full Name
    secreted frizzled-related protein 1provided by MGI
    Primary source
    MGI:MGI:892014
    See related
    Ensembl:ENSMUSG00000031548 Vega:OTTMUSG00000021102
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sFRP-1; AW011917; AW107218; AW742929; 2210415K03Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 23.7), CNS E11.5 (RPKM 22.8) and 26 other tissues See more
    Orthologs
    Location:
    8 A2; 8 11.48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (23411382..23449632)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (24521974..24560104)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39141 Neighboring gene golgi autoantigen, golgin subfamily a, 7 Neighboring gene predicted gene, 30370 Neighboring gene RIKEN cDNA 4930413E20 gene Neighboring gene predicted gene, 30471 Neighboring gene zinc finger, matrin type 4

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • BMP Signaling Pathway in Eyelid Development, organism-specific biosystem (from WikiPathways)
      BMP Signaling Pathway in Eyelid Development, organism-specific biosystemThe signaling pathways involved in eyelid development are displayed with interactions that are known (solid arrows) and proposed (dotted arrows). The four main pathways shown are activated by Fgf10 a...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Wnt-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    drug binding ISO
    Inferred from Sequence Orthology
    more info
     
    frizzled binding ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway involved in somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Wnt signaling pathway, planar cell polarity pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    bone trabecula formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to X-ray IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to estrogen stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to estrogen stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heparin ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    convergent extension involved in somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    development of primary male sexual characteristics IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    digestive tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dopaminergic neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dorsal/ventral axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    female gonad development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    hematopoietic stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male gonad development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of JUN kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of planar cell polarity pathway involved in axis elongation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neural crest cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube closure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neural tube development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    planar cell polarity pathway involved in neural tube closure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of non-canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of branching involved in prostate gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of establishment of planar polarity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of midbrain dopaminergic neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somitogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    stromal-epithelial cell signaling involved in prostate gland development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ureteric bud development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space HDA PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    secreted frizzled-related protein 1
    Names
    secreted frizzled-related sequence protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013834.3NP_038862.2  secreted frizzled-related protein 1 precursor

      See identical proteins and their annotated locations for NP_038862.2

      Status: VALIDATED

      Source sequence(s)
      AK081052, BB620977, BC094662
      Consensus CDS
      CCDS22191.1
      UniProtKB/Swiss-Prot
      Q8C4U3
      Related
      ENSMUSP00000033952.7, OTTMUSP00000023228, ENSMUST00000033952.7, OTTMUST00000049933
      Conserved Domains (2) summary
      cd07443
      Location:52175
      CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity
      cd03580
      Location:183306
      NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      23411382..23449632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242128.1XP_011240430.1  secreted frizzled-related protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011240430.1

      UniProtKB/Swiss-Prot
      Q8C4U3
      Conserved Domains (2) summary
      cd07443
      Location:52175
      CRD_SFRP1; Cysteine-rich domain of the secreted frizzled-related protein 1 (SFRP1), a regulator of Wnt activity
      cd03580
      Location:183306
      NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...
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