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    Hspa9 heat shock protein 9 [ Mus musculus (house mouse) ]

    Gene ID: 15526, updated on 8-Apr-2018
    Official Symbol
    Hspa9provided by MGI
    Official Full Name
    heat shock protein 9provided by MGI
    Primary source
    MGI:MGI:96245
    See related
    Ensembl:ENSMUSG00000024359 Vega:OTTMUSG00000037646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csa; Mot2; 74kDa; Grp75; Hsc74; Hsp74; Mot-2; Pbp74; Hsp74a; Hspa9a; Mthsp70; Mortalin
    Expression
    Ubiquitous expression in liver E18 (RPKM 85.2), placenta adult (RPKM 77.5) and 28 other tissues See more
    Orthologs
    Location:
    18 B1; 18 18.8 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (34937414..34954351, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (35097068..35114005, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene early growth response 1 Neighboring gene eukaryotic translation termination factor 1 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene Neighboring gene predicted gene, 36037 Neighboring gene predicted gene, 41690

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ATPase activity, coupled IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding involved in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    stress-70 protein, mitochondrial
    Names
    75 kDa glucose-regulated protein
    C3H-specific antigen
    GRP-75
    heat shock 70 kDa protein 9
    heat shock protein 9A
    heat shock protein cognate 74
    heat shock protein, 74 kDa, A
    heat shock protein, A
    p66 MOT
    peptide-binding protein 74

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010481.2NP_034611.2  stress-70 protein, mitochondrial

      See identical proteins and their annotated locations for NP_034611.2

      Status: VALIDATED

      Source sequence(s)
      BC057343, BP769296
      Consensus CDS
      CCDS29138.1
      UniProtKB/Swiss-Prot
      P38647
      Related
      ENSMUSP00000025217.8, OTTMUSP00000054429, ENSMUST00000025217.8, OTTMUST00000097161
      Conserved Domains (2) summary
      cd11733
      Location:52428
      HSPA9-like_NBD; Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins
      PRK00290
      Location:52673
      dnaK; molecular chaperone DnaK; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      34937414..34954351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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