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    Gch1 GTP cyclohydrolase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14528, updated on 14-Apr-2018
    Official Symbol
    Gch1provided by MGI
    Official Full Name
    GTP cyclohydrolase 1provided by MGI
    Primary source
    MGI:MGI:95675
    See related
    Ensembl:ENSMUSG00000037580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gch; GTPCH; GTP-CH; GTP-CH-I
    Expression
    Biased expression in liver adult (RPKM 53.7), adrenal adult (RPKM 35.5) and 10 other tissues See more
    Orthologs
    Location:
    14 C1; 14 24.6 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (47153895..47189402, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (47773570..47809077, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 4 Neighboring gene microRNA 378c Neighboring gene predicted gene 10371 Neighboring gene poly(A) binding protein, cytoplasmic 2 pseudogene Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene suppressor of cytokine signaling 4

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTP cyclohydrolase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    GTP cyclohydrolase I activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP cyclohydrolase I activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to lipopolysaccharide TAS
    Traceable Author Statement
    more info
    PubMed 
    dihydrobiopterin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    dopamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process controlling posture ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    pteridine-containing compound biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lung blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of removal of superoxide radicals ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of serotonin biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    tetrahydrobiopterin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tetrahydrobiopterin biosynthetic process IC
    Inferred by Curator
    more info
    PubMed 
    tetrahydrobiopterin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    GTP cyclohydrolase 1
    Names
    GTP cyclohydrolase I
    NP_032128.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008102.4NP_032128.1  GTP cyclohydrolase 1 precursor

      See identical proteins and their annotated locations for NP_032128.1

      Status: VALIDATED

      Source sequence(s)
      AC154589, AC159006
      Consensus CDS
      CCDS26984.1
      UniProtKB/Swiss-Prot
      Q05915
      UniProtKB/TrEMBL
      Q3U7P6
      Related
      ENSMUSP00000087405.6, ENSMUST00000089959.6
      Conserved Domains (2) summary
      pfam01543
      Location:451
      HCV_capsid; Hepatitis C virus capsid protein
      cd00642
      Location:57241
      GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      47153895..47189402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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