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    TANGO2 transport and golgi organization 2 homolog [ Homo sapiens (human) ]

    Gene ID: 128989, updated on 21-Apr-2018
    Official Symbol
    TANGO2provided by HGNC
    Official Full Name
    transport and golgi organization 2 homologprovided by HGNC
    Primary source
    HGNC:HGNC:25439
    See related
    Ensembl:ENSG00000183597 MIM:616830; Vega:OTTHUMG00000150510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MECRCN; C22orf25
    Summary
    This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in heart (RPKM 11.7), bone marrow (RPKM 9.2) and 25 other tissues See more
    Orthologs
    Location:
    22q11.21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (20017000..20067164)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (20004554..20053449)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene catechol-O-methyltransferase Neighboring gene microRNA 4761 Neighboring gene ARVCF, delta catenin family member Neighboring gene microRNA 185 Neighboring gene DGCR8, microprocessor complex subunit Neighboring gene microRNA 3618 Neighboring gene microRNA 1306

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp761P1121

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    transport and Golgi organization protein 2 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046857.1 RefSeqGene

      Range
      5001..55165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001283106.2NP_001270035.1  transport and Golgi organization protein 2 homolog isoform a

      See identical proteins and their annotated locations for NP_001270035.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK289862, BC041339, DC303300, HY135099
      Consensus CDS
      CCDS13772.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      UniProtKB/TrEMBL
      A8K1E7
      Conserved Domains (1) summary
      pfam05742
      Location:1259
      TANGO2; Transport and Golgi organization 2
    2. NM_001283116.2NP_001270045.1  transport and Golgi organization protein 2 homolog isoform a

      See identical proteins and their annotated locations for NP_001270045.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, BC041339, CF552364, DA176876, DC318353
      Consensus CDS
      CCDS13772.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:1259
      TANGO2; Transport and Golgi organization 2
    3. NM_001283129.2NP_001270058.1  transport and Golgi organization protein 2 homolog isoform b

      See identical proteins and their annotated locations for NP_001270058.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK316056, BC041339, DA176876, DC318353
      Consensus CDS
      CCDS63405.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Related
      ENSP00000403645.2, ENST00000456048.5
      Conserved Domains (1) summary
      pfam05742
      Location:60300
      TANGO2; Transport and Golgi organization 2
    4. NM_001283148.2NP_001270077.1  transport and Golgi organization protein 2 homolog isoform c

      See identical proteins and their annotated locations for NP_001270077.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK316020, BC041339, DA176876, DC318353
      UniProtKB/Swiss-Prot
      Q6ICL3
      UniProtKB/TrEMBL
      B7Z9Q5
      Conserved Domains (1) summary
      pfam05742
      Location:1201
      TANGO2; Transport and Golgi organization 2
    5. NM_001283154.2NP_001270083.1  transport and Golgi organization protein 2 homolog isoform c

      See identical proteins and their annotated locations for NP_001270083.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, BC041339, BI544307, BU173566, DA176876, DC318353
      UniProtKB/Swiss-Prot
      Q6ICL3
      UniProtKB/TrEMBL
      B7Z9Q5
      Conserved Domains (1) summary
      pfam05742
      Location:1201
      TANGO2; Transport and Golgi organization 2
    6. NM_001283179.2NP_001270108.1  transport and Golgi organization protein 2 homolog isoform d

      See identical proteins and their annotated locations for NP_001270108.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, BC041339, BX345246, DC303300, HY135099
      Consensus CDS
      CCDS63404.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Related
      ENSP00000385662.1, OTTHUMP00000197694, ENST00000401886.5, OTTHUMT00000318687
      Conserved Domains (1) summary
      pfam05742
      Location:1197
      TANGO2; Transport and Golgi organisation 2
    7. NM_001283186.2NP_001270115.1  transport and Golgi organization protein 2 homolog isoform d

      See identical proteins and their annotated locations for NP_001270115.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK092484, BC041339, DA176876, DC318353
      Consensus CDS
      CCDS63404.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Related
      ENSP00000381122.2, OTTHUMP00000197727, ENST00000398042.6, OTTHUMT00000318725
      Conserved Domains (1) summary
      pfam05742
      Location:1197
      TANGO2; Transport and Golgi organisation 2
    8. NM_001283199.2NP_001270128.1  transport and Golgi organization protein 2 homolog isoform e

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, BC041339, BI544307, BI911898, DA176876, DC318353
      Consensus CDS
      CCDS74821.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      UniProtKB/TrEMBL
      A0A0A0MSI5
      Related
      ENSP00000389797.3, ENST00000447208.6
      Conserved Domains (1) summary
      pfam05742
      Location:1184
      TANGO2; Transport and Golgi organization 2
    9. NM_001283215.2NP_001270144.1  transport and Golgi organization protein 2 homolog isoform f

      See identical proteins and their annotated locations for NP_001270144.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK301366, AK316056, BC041339, DA176876, DC318353
      Consensus CDS
      CCDS63406.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Related
      ENSP00000391262.2, ENST00000434570.6
      Conserved Domains (1) summary
      pfam05742
      Location:60192
      TANGO2; Transport and Golgi organization 2
    10. NM_001283235.2NP_001270164.1  transport and Golgi organization protein 2 homolog isoform g

      See identical proteins and their annotated locations for NP_001270164.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK298593, BC041339, DA176876, DC318353
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Related
      ENSP00000402926.2, ENST00000432883.5
      Conserved Domains (1) summary
      cl01315
      Location:32161
      TANGO2; Transport and Golgi organisation 2
    11. NM_001283248.2NP_001270177.1  transport and Golgi organization protein 2 homolog isoform h

      See identical proteins and their annotated locations for NP_001270177.1

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK297075, BC041339, DA176876, DC318353
      Consensus CDS
      CCDS74822.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      UniProtKB/TrEMBL
      B7Z4A5
      Related
      ENSP00000396182.3, ENST00000420290.6
      Conserved Domains (1) summary
      cl01315
      Location:189
      TANGO2; Transport and Golgi organization 2
    12. NM_001322141.1NP_001309070.1  transport and Golgi organization protein 2 homolog isoform i

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, BG685068, BP193987
      Conserved Domains (1) summary
      pfam05742
      Location:60352
      TANGO2; Transport and Golgi organization 2
    13. NM_001322142.1NP_001309071.1  transport and Golgi organization protein 2 homolog isoform j

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      pfam05742
      Location:1311
      TANGO2; Transport and Golgi organization 2
    14. NM_001322143.1NP_001309072.1  transport and Golgi organization protein 2 homolog isoform b

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, AL713640, BM013784, DB021425
      Consensus CDS
      CCDS63405.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Related
      ENSP00000384827.1, OTTHUMP00000197697, ENST00000401833.5, OTTHUMT00000318691
      Conserved Domains (1) summary
      pfam05742
      Location:60300
      TANGO2; Transport and Golgi organization 2
    15. NM_001322144.1NP_001309073.1  transport and Golgi organization protein 2 homolog isoform l

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      pfam05742
      Location:60242
      TANGO2; Transport and Golgi organization 2
    16. NM_001322145.1NP_001309074.1  transport and Golgi organization protein 2 homolog isoform m

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      pfam05742
      Location:60238
      TANGO2; Transport and Golgi organization 2
    17. NM_001322146.1NP_001309075.1  transport and Golgi organization protein 2 homolog isoform k

      Status: REVIEWED

      Source sequence(s)
      AA319727, AC005663, AC006547
      Conserved Domains (1) summary
      pfam05742
      Location:55277
      TANGO2; Transport and Golgi organization 2
    18. NM_001322147.1NP_001309076.1  transport and Golgi organization protein 2 homolog isoform m

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      pfam05742
      Location:60238
      TANGO2; Transport and Golgi organization 2
    19. NM_001322148.1NP_001309077.1  transport and Golgi organization protein 2 homolog isoform n

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, AK316056, BM048105
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:55225
      TANGO2; Transport and Golgi organization 2
    20. NM_001322149.1NP_001309078.1  transport and Golgi organization protein 2 homolog isoform r

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, BI911898, DC349456
      Conserved Domains (1) summary
      pfam05742
      Location:60225
      TANGO2; Transport and Golgi organization 2
    21. NM_001322150.1NP_001309079.1  transport and Golgi organization protein 2 homolog isoform o

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, BP193987
      Conserved Domains (1) summary
      cl01315
      Location:32213
      TANGO2; Transport and Golgi organization 2
    22. NM_001322153.1NP_001309082.1  transport and Golgi organization protein 2 homolog isoform o

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, DC301369, DC315148
      Conserved Domains (1) summary
      cl01315
      Location:32213
      TANGO2; Transport and Golgi organization 2
    23. NM_001322155.1NP_001309084.1  transport and Golgi organization protein 2 homolog isoform o

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      cl01315
      Location:32213
      TANGO2; Transport and Golgi organization 2
    24. NM_001322160.1NP_001309089.1  transport and Golgi organization protein 2 homolog isoform p

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      cl01315
      Location:55167
      TANGO2; Transport and Golgi organization 2
    25. NM_001322163.1NP_001309092.1  transport and Golgi organization protein 2 homolog isoform d

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63404.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:1197
      TANGO2; Transport and Golgi organisation 2
    26. NM_001322166.1NP_001309095.1  transport and Golgi organization protein 2 homolog isoform d

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63404.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:1197
      TANGO2; Transport and Golgi organisation 2
    27. NM_001322167.1NP_001309096.1  transport and Golgi organization protein 2 homolog isoform d

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63404.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      pfam05742
      Location:1197
      TANGO2; Transport and Golgi organisation 2
    28. NM_001322169.1NP_001309098.1  transport and Golgi organization protein 2 homolog isoform q

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Conserved Domains (1) summary
      pfam05742
      Location:1139
      TANGO2; Transport and Golgi organization 2
    29. NM_001322171.1NP_001309100.1  transport and Golgi organization protein 2 homolog isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, BF726547, CD675132
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      cl01315
      Location:32161
      TANGO2; Transport and Golgi organisation 2
    30. NM_001322172.1NP_001309101.1  transport and Golgi organization protein 2 homolog isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547, BF726547
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      cl01315
      Location:32161
      TANGO2; Transport and Golgi organisation 2
    31. NM_001322173.1NP_001309102.1  transport and Golgi organization protein 2 homolog isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      cl01315
      Location:32161
      TANGO2; Transport and Golgi organisation 2
    32. NM_001322174.1NP_001309103.1  transport and Golgi organization protein 2 homolog isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      cl01315
      Location:32161
      TANGO2; Transport and Golgi organisation 2
    33. NM_001322175.1NP_001309104.1  transport and Golgi organization protein 2 homolog isoform g

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
      Consensus CDS
      CCDS63407.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      cl01315
      Location:32161
      TANGO2; Transport and Golgi organisation 2
    34. NM_152906.6NP_690870.3  transport and Golgi organization protein 2 homolog isoform a

      See identical proteins and their annotated locations for NP_690870.3

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK297922, BC041339, DA176876, DC318353
      Consensus CDS
      CCDS13772.1
      UniProtKB/Swiss-Prot
      Q6ICL3
      UniProtKB/TrEMBL
      B7Z4V5
      Related
      ENSP00000332721.4, OTTHUMP00000197696, ENST00000327374.8, OTTHUMT00000318689
      Conserved Domains (1) summary
      pfam05742
      Location:1259
      TANGO2; Transport and Golgi organization 2

    RNA

    1. NR_104274.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AA969089, AC006547, AK301054, BC041339, DA176876, DC318353
    2. NR_104275.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
    3. NR_136206.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547
    4. NR_136211.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC006547, BI544307, BP303570
    5. NR_136212.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC005663, AC006547

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

      Range
      20017000..20067164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028581.1XP_016884070.1  transport and Golgi organization protein 2 homolog isoform X2

      Conserved Domains (1) summary
      pfam05742
      Location:55277
      TANGO2; Transport and Golgi organization 2
    2. XM_017028587.1XP_016884076.1  transport and Golgi organization protein 2 homolog isoform X4

      Conserved Domains (1) summary
      pfam05742
      Location:55225
      TANGO2; Transport and Golgi organization 2
    3. XM_017028579.1XP_016884068.1  transport and Golgi organization protein 2 homolog isoform X1

      Conserved Domains (1) summary
      pfam05742
      Location:1311
      TANGO2; Transport and Golgi organization 2
    4. XM_017028582.1XP_016884071.1  transport and Golgi organization protein 2 homolog isoform X2

      Conserved Domains (1) summary
      pfam05742
      Location:55277
      TANGO2; Transport and Golgi organization 2
    5. XM_017028580.1XP_016884069.1  transport and Golgi organization protein 2 homolog isoform X1

      Conserved Domains (1) summary
      pfam05742
      Location:1311
      TANGO2; Transport and Golgi organization 2
    6. XM_011529867.1XP_011528169.1  transport and Golgi organization protein 2 homolog isoform X7

      See identical proteins and their annotated locations for XP_011528169.1

      UniProtKB/Swiss-Prot
      Q6ICL3
      Conserved Domains (1) summary
      cl01315
      Location:32161
      TANGO2; Transport and Golgi organisation 2
    7. XM_017028586.1XP_016884075.1  transport and Golgi organization protein 2 homolog isoform X3

    8. XM_017028584.1XP_016884073.1  transport and Golgi organization protein 2 homolog isoform X2

      Conserved Domains (1) summary
      pfam05742
      Location:55277
      TANGO2; Transport and Golgi organization 2
    9. XM_011529863.1XP_011528165.1  transport and Golgi organization protein 2 homolog isoform X5

      Conserved Domains (1) summary
      cl01315
      Location:55167
      TANGO2; Transport and Golgi organization 2
    10. XM_017028577.1XP_016884066.1  transport and Golgi organization protein 2 homolog isoform X1

      Conserved Domains (1) summary
      pfam05742
      Location:1311
      TANGO2; Transport and Golgi organization 2
    11. XM_017028585.1XP_016884074.1  transport and Golgi organization protein 2 homolog isoform X3

    12. XM_017028583.1XP_016884072.1  transport and Golgi organization protein 2 homolog isoform X2

      Conserved Domains (1) summary
      pfam05742
      Location:55277
      TANGO2; Transport and Golgi organization 2
    13. XM_017028588.2XP_016884077.1  transport and Golgi organization protein 2 homolog isoform X8

      Related
      ENSP00000415450.1, OTTHUMP00000197729, ENST00000450664.5
      Conserved Domains (1) summary
      pfam05742
      Location:1151
      TANGO2; Transport and Golgi organization 2
    14. XM_017028578.1XP_016884067.1  transport and Golgi organization protein 2 homolog isoform X1

      Conserved Domains (1) summary
      pfam05742
      Location:1311
      TANGO2; Transport and Golgi organization 2
    15. XM_024452157.1XP_024307925.1  transport and Golgi organization protein 2 homolog isoform X7

      Conserved Domains (1) summary
      cl01315
      Location:32161
      TANGO2; Transport and Golgi organisation 2
    16. XM_011529865.1XP_011528167.1  transport and Golgi organization protein 2 homolog isoform X6

      Conserved Domains (1) summary
      pfam05742
      Location:24156
      TANGO2; Transport and Golgi organization 2

    RNA

    1. XR_001755164.1 RNA Sequence

      Related
      ENST00000399807.7, OTTHUMT00000318690
    2. XR_002958662.1 RNA Sequence

    3. XR_001755161.1 RNA Sequence

    4. XR_001755163.1 RNA Sequence

    5. XR_001755162.1 RNA Sequence

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