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    Miga2 mitoguardin 2 [ Mus musculus (house mouse) ]

    Gene ID: 108958, updated on 6-Feb-2018
    Official Symbol
    Miga2provided by MGI
    Official Full Name
    mitoguardin 2provided by MGI
    Primary source
    MGI:MGI:1922035
    See related
    Ensembl:ENSMUSG00000026858 Vega:OTTMUSG00000016796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam73b; R74766; C9orf54; AA408683; AI790341; 5730472N09Rik
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 26.5), mammary gland adult (RPKM 21.5) and 28 other tissues See more
    Orthologs
    Location:
    2; 2 B
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (30364198..30385520)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (30219855..30241039)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene nucleoporin 188 Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase Neighboring gene protein phosphatase 2 protein activator

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    mitoguardin 2; mitoguardin-2
    Names
    family with sequence similarity 73, member B
    mFLJ00199 protein
    ortholog of family with sequence similarity 73, member B FAM73B
    protein FAM73B

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242407.1NP_001229336.1  mitoguardin 2

      See identical proteins and their annotated locations for NP_001229336.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK077618, AW049066, BY151776
      Consensus CDS
      CCDS15880.1
      UniProtKB/Swiss-Prot
      Q8BK03
      Related
      ENSMUSP00000077127.7, OTTMUSP00000018231, ENSMUST00000077977.13, OTTMUST00000040765
      Conserved Domains (1) summary
      pfam10265
      Location:31568
      DUF2217; Uncharacterized conserved protein (DUF2217)
    2. NM_175392.3NP_780601.1  mitoguardin 2

      See identical proteins and their annotated locations for NP_780601.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC051404
      Consensus CDS
      CCDS15880.1
      UniProtKB/Swiss-Prot
      Q8BK03
      Related
      ENSMUSP00000097787.3, OTTMUSP00000018232, ENSMUST00000100214.9, OTTMUST00000040766
      Conserved Domains (1) summary
      pfam10265
      Location:31568
      DUF2217; Uncharacterized conserved protein (DUF2217)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      30364198..30385520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497595.2XP_006497658.1  mitoguardin-2 isoform X3

      Conserved Domains (1) summary
      pfam10265
      Location:30377
      DUF2217; Uncharacterized conserved protein (DUF2217)
    2. XM_006497593.2XP_006497656.1  mitoguardin-2 isoform X1

      Conserved Domains (1) summary
      pfam10265
      Location:117654
      DUF2217; Uncharacterized conserved protein (DUF2217)
    3. XM_006497594.2XP_006497657.1  mitoguardin-2 isoform X2

      Conserved Domains (1) summary
      pfam10265
      Location:117615
      DUF2217; Uncharacterized conserved protein (DUF2217)

    RNA

    1. XR_001780361.1 RNA Sequence

    2. XR_866005.1 RNA Sequence

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