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    IL20RB interleukin 20 receptor subunit beta [ Homo sapiens (human) ]

    Gene ID: 53833, updated on 2-Oct-2018

    Summary

    Official Symbol
    IL20RBprovided by HGNC
    Official Full Name
    interleukin 20 receptor subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:6004
    See related
    Ensembl:ENSG00000174564 MIM:605621; Vega:OTTHUMG00000159779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DIRS1; FNDC6; IL-20R2
    Summary
    IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]
    Expression
    Biased expression in skin (RPKM 54.3) and esophagus (RPKM 20.8) See more
    Orthologs

    Genomic context

    See IL20RB in Genome Data Viewer
    Location:
    3q22.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (136957865..137011085)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136676707..136729927)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member G2 Neighboring gene NCK1 divergent transcript Neighboring gene RAD51 associated protein 1 pseudogene 1 Neighboring gene NCK adaptor protein 1 Neighboring gene IL20RB antisense RNA 1 Neighboring gene VISTA enhancer hs208 Neighboring gene VISTA enhancer hs209

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    NHGRI GWA Catalog
    Genome-wide association study of co-occurring anxiety in major depression.
    NHGRI GWA Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-19, 20, 22, 24, organism-specific biosystem (from REACTOME)
      Interleukin-19, 20, 22, 24, organism-specific biosystemThe interleukin-20 (IL20) subfamily comprises IL19, IL-20, IL-22, IL-24 and IL-26. They are members of the larger IL-10 family, but have been grouped together based on their usage of common receptor ...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC34923

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    interleukin-20 binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    homeostasis of number of cells within a tissue IEA
    Inferred from Electronic Annotation
    more info
     
    immune response-inhibiting signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response to antigenic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of interleukin-2 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of type IV hypersensitivity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-20 receptor subunit beta
    Names
    IL-20 receptor subunit beta
    IL-20R-beta
    IL-20RB
    fibronectin type III domain containing 6
    interleukin 20 receptor beta subunit
    interleukin-20 receptor II

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144717.3NP_653318.2  interleukin-20 receptor subunit beta precursor

      See identical proteins and their annotated locations for NP_653318.2

      Status: VALIDATED

      Source sequence(s)
      AY358305, BC063696
      Consensus CDS
      CCDS3093.1
      UniProtKB/Swiss-Prot
      Q6UXL0
      Related
      ENSP00000328133.4, OTTHUMP00000216468, ENST00000329582.8, OTTHUMT00000357277
      Conserved Domains (2) summary
      pfam01108
      Location:30124
      Tissue_fac; Tissue factor
      cl21522
      Location:136225
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      136957865..137011085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512910.3XP_011511212.1  interleukin-20 receptor subunit beta isoform X1

      Conserved Domains (2) summary
      pfam01108
      Location:35129
      Tissue_fac; Tissue factor
      cl21522
      Location:141230
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_011512911.2XP_011511213.1  interleukin-20 receptor subunit beta isoform X2

      See identical proteins and their annotated locations for XP_011511213.1

      Conserved Domains (2) summary
      pfam01108
      Location:177
      Tissue_fac; Tissue factor
      cl21522
      Location:89178
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    3. XM_017006632.1XP_016862121.1  interleukin-20 receptor subunit beta isoform X2

      Conserved Domains (2) summary
      pfam01108
      Location:177
      Tissue_fac; Tissue factor
      cl21522
      Location:89178
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    4. XM_006713665.4XP_006713728.1  interleukin-20 receptor subunit beta isoform X2

      See identical proteins and their annotated locations for XP_006713728.1

      Conserved Domains (2) summary
      pfam01108
      Location:177
      Tissue_fac; Tissue factor
      cl21522
      Location:89178
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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