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    HRNR hornerin [ Homo sapiens (human) ]

    Gene ID: 388697, updated on 28-Oct-2018

    Summary

    Official Symbol
    HRNRprovided by HGNC
    Official Full Name
    hornerinprovided by HGNC
    Primary source
    HGNC:HGNC:20846
    See related
    Ensembl:ENSG00000197915 MIM:616293; Vega:OTTHUMG00000012243
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLG3; S100A16; S100a18
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See HRNR in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (152212076..152224196, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152184552..152196672, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene repetin Neighboring gene uncharacterized LOC112268240 Neighboring gene FLG antisense RNA 1 Neighboring gene filaggrin Neighboring gene filaggrin family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated hornerin (HRNR) protein is incorporated into HIV-1 Gag virus-like particles PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural constituent of epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell envelope organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment of skin barrier IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    establishment of skin barrier IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    keratinization IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    collagen-containing extracellular matrix HDA PubMed 
    cornified envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cornified envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    keratohyalin granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    keratohyalin granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus HDA PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    hornerin
    Names
    filaggrin family member 3
    intermediate filament-associated protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009931.2NP_001009931.1  hornerin

      See identical proteins and their annotated locations for NP_001009931.1

      Status: VALIDATED

      Source sequence(s)
      AY396741, BR000036
      Consensus CDS
      CCDS30859.1
      UniProtKB/Swiss-Prot
      Q86YZ3
      Related
      ENSP00000357791.2, OTTHUMP00000014118, ENST00000368801.2, OTTHUMT00000034016
      Conserved Domains (2) summary
      cd00213
      Location:289
      S-100; S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
      pfam13499
      Location:2475
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      152212076..152224196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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