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    TSACC TSSK6 activating cochaperone [ Homo sapiens (human) ]

    Gene ID: 128229, updated on 5-Aug-2018

    Summary

    Official Symbol
    TSACCprovided by HGNC
    Official Full Name
    TSSK6 activating cochaperoneprovided by HGNC
    Primary source
    HGNC:HGNC:30636
    See related
    Ensembl:ENSG00000163467 Vega:OTTHUMG00000024060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIP; SSTK-IP; C1orf182
    Expression
    Restricted expression toward testis (RPKM 148.3) See more
    Orthologs

    Genomic context

    See TSACC in Genome Data Viewer
    Location:
    1q22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (156337314..156346995)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156307105..156316786)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene glycosylated lysosomal membrane protein Neighboring gene VHL like Neighboring gene chaperonin containing TCP1 subunit 3 Neighboring gene Rh family B glycoprotein (gene/pseudogene) Neighboring gene chromosome 1 open reading frame 61 Neighboring gene microRNA 9-1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC26877

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    TSSK6-activating co-chaperone protein
    Names
    SSTK-interacting protein (SSTK-IP)
    TSSK6 activating co-chaperone

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304817.1NP_001291746.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_001291746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AK311950, BC014605, DB446801
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      Q96A04
      Related
      ENSP00000357237.1, OTTHUMP00000025733, ENST00000368254.5, OTTHUMT00000060598
      Conserved Domains (1) summary
      pfam15836
      Location:1125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    2. NM_001304818.1NP_001291747.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_001291747.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AY048672, DB446801
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      Q96A04
      Related
      ENSP00000357236.1, OTTHUMP00000025731, ENST00000368253.6, OTTHUMT00000060595
      Conserved Domains (1) summary
      pfam15836
      Location:1125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    3. NM_001304819.1NP_001291748.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_001291748.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      BC014605, HY019225, HY044099
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      Q96A04
      Related
      ENSP00000357235.1, OTTHUMP00000025732, ENST00000368252.5, OTTHUMT00000060596
      Conserved Domains (1) summary
      pfam15836
      Location:1125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    4. NM_001304820.1NP_001291749.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_001291749.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AI336861, BC014605
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      Q96A04
      Related
      ENSP00000357234.1, OTTHUMP00000025734, ENST00000368251.1, OTTHUMT00000060601
      Conserved Domains (1) summary
      pfam15836
      Location:1125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    5. NM_001304821.1NP_001291750.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_001291750.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      BC014605, HY044099, HY230397
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      Q96A04
      Conserved Domains (1) summary
      pfam15836
      Location:1125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    6. NM_001304822.1NP_001291751.1  TSSK6-activating co-chaperone protein isoform b

      See identical proteins and their annotated locations for NP_001291751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
      Source sequence(s)
      BC014605, DB446801, HY044771
      Consensus CDS
      CCDS76223.1
      UniProtKB/Swiss-Prot
      Q96A04
      UniProtKB/TrEMBL
      V9GYT6
      Conserved Domains (1) summary
      pfam15836
      Location:157
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    7. NM_001304823.1NP_001291752.1  TSSK6-activating co-chaperone protein isoform b

      See identical proteins and their annotated locations for NP_001291752.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
      Source sequence(s)
      BC014605, DB446801, HY034095
      Consensus CDS
      CCDS76223.1
      UniProtKB/Swiss-Prot
      Q96A04
      UniProtKB/TrEMBL
      V9GYT6
      Related
      ENSP00000477074.1, OTTHUMP00000273939, ENST00000470342.5, OTTHUMT00000060597
      Conserved Domains (1) summary
      pfam15836
      Location:157
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    8. NM_001304824.1NP_001291753.1  TSSK6-activating co-chaperone protein isoform b

      See identical proteins and their annotated locations for NP_001291753.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
      Source sequence(s)
      BC014605, BE464129, HY044099
      Consensus CDS
      CCDS76223.1
      UniProtKB/Swiss-Prot
      Q96A04
      UniProtKB/TrEMBL
      V9GYT6
      Related
      ENSP00000477010.1, OTTHUMP00000273941, ENST00000466306.5, OTTHUMT00000060600
      Conserved Domains (1) summary
      pfam15836
      Location:157
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    9. NM_001304825.1NP_001291754.1  TSSK6-activating co-chaperone protein isoform b

      See identical proteins and their annotated locations for NP_001291754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) uses an alternate splice junction at the 5' end of the last exon compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 7, 8, 9, and 10 all encode the same isoform (b).
      Source sequence(s)
      BC014605, BI831108, HY044099
      Consensus CDS
      CCDS76223.1
      UniProtKB/Swiss-Prot
      Q96A04
      UniProtKB/TrEMBL
      V9GYT6
      Related
      ENSP00000476780.1, OTTHUMP00000273940, ENST00000481479.5, OTTHUMT00000060599
      Conserved Domains (1) summary
      pfam15836
      Location:157
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    10. NM_001304826.1NP_001291755.1  TSSK6-activating co-chaperone protein isoform c

      See identical proteins and their annotated locations for NP_001291755.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and uses two alternate splice junctions at the 5' end compared to variant 1. The resulting isoform (c) is longer at the N-terminus compared to isoform a.
      Source sequence(s)
      AY048673, HY044099
      UniProtKB/Swiss-Prot
      Q96A04
      Conserved Domains (1) summary
      pfam15836
      Location:19143
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein
    11. NM_144627.4NP_653228.1  TSSK6-activating co-chaperone protein isoform a

      See identical proteins and their annotated locations for NP_653228.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, and 6 all encode the same isoform (a).
      Source sequence(s)
      AL589685, BC014605
      Consensus CDS
      CCDS1141.1
      UniProtKB/Swiss-Prot
      Q96A04
      Related
      ENSP00000357238.3, OTTHUMP00000025730, ENST00000368255.7, OTTHUMT00000060594
      Conserved Domains (1) summary
      pfam15836
      Location:1125
      SSTK-IP; SSTK-interacting protein, TSSK6-activating co-chaperone protein

    RNA

    1. NR_130913.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) differs at the 5' end, lacks an alternate internal exon, and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      BC014605, DB446801, HY048925

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      156337314..156346995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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