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    CCNT2 cyclin T2 [ Homo sapiens (human) ]

    Gene ID: 905, updated on 17-Jun-2024

    Summary

    Official Symbol
    CCNT2provided by HGNC
    Official Full Name
    cyclin T2provided by HGNC
    Primary source
    HGNC:HGNC:1600
    See related
    Ensembl:ENSG00000082258 MIM:603862; AllianceGenome:HGNC:1600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CYCT2
    Summary
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 8.2), testis (RPKM 7.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CCNT2 in Genome Data Viewer
    Location:
    2q21.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (134918822..134959342)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (135359158..135399741)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (135676392..135716912)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak3872 silencer Neighboring gene aminocarboxymuconate semialdehyde decarboxylase Neighboring gene microRNA 5590 Neighboring gene CCNT2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:135675361-135676034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11979 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16569 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135732781-135733282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:135733283-135733782 Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene MPRA-validated peak3873 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16570 Neighboring gene small nucleolar RNA U13 Neighboring gene RAB3 GTPase activating protein catalytic subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Cyclin T2 competes with cyclin T1 for binding to CDK9 and can thereby inhibit HIV-1 Tat activity PubMed
    tat Amino acids 260-263 of cyclin T1 are critical for HIV-1 Tat-mediated transcriptional activation, and site-directed mutations in this region of cyclin T2 (asparagine to cysteine at residue 260) allow it to bind Tat and stimulate transcription PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13583, FLJ90560, MGC134840

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 7SK snRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cyclin/CDK positive transcription elongation factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    cyclin-T2
    Names
    SDS-stable vimentin-bound DNA fragment HEF42VIM22
    cyclin T2a
    cyclin T2b
    subunit of positive elongation transcription factor b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029189.1 RefSeqGene

      Range
      5001..45521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001241.4NP_001232.1  cyclin-T2 isoform a

      See identical proteins and their annotated locations for NP_001232.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) encodes isoform a.
      Source sequence(s)
      AC016725, AK294889, AU157699, BC114366
      Consensus CDS
      CCDS2175.1
      UniProtKB/Swiss-Prot
      O60583
      UniProtKB/TrEMBL
      B4DH21
      Related
      ENSP00000295238.6, ENST00000295238.11
      Conserved Domains (2) summary
      COG5333
      Location:8216
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
      cd00043
      Location:37108
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    2. NM_001320748.2NP_001307677.1  cyclin-T2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) contains an alternate internal exon and an alternate internal segment in the 3' end compared to variant a. The resulting isoform (d) has a shorter and distinct N-terminus and a longer and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC016725, AK294889, BI769278
      UniProtKB/TrEMBL
      B4DH21
      Conserved Domains (1) summary
      cl02571
      Location:152283
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    3. NM_001320749.2NP_001307678.1  cyclin-T2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) contains an alternate internal exon and an alternate internal segment in the 3' end compared to variant a. The resulting isoform (e) is shorter at the N-terminus and has a longer and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC016725, AK294889
      UniProtKB/TrEMBL
      B4DH21
      Conserved Domains (1) summary
      COG5422
      Location:121252
      ROM1; RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]
    4. NM_058241.3NP_490595.1  cyclin-T2 isoform b

      See identical proteins and their annotated locations for NP_490595.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) contains an additional internal fragment in the 3' coding region, which results in a frameshift, compared to variant a. The resulting isoform (b) is longer and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC016725, AK292913, AK294889
      Consensus CDS
      CCDS2174.1
      UniProtKB/Swiss-Prot
      A8KA48, D3DP73, D3DP74, O60582, O60583, Q29R66, Q53SR4, Q5I1Y0
      Related
      ENSP00000264157.5, ENST00000264157.10
      Conserved Domains (2) summary
      COG5333
      Location:8216
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
      cd00043
      Location:37108
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RNA

    1. NR_037649.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) has an addition exon, compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC016725, AK294889
    2. NR_135468.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) contains an alternate exon, uses an alternate splice junction, and contains an alternate segment in the 3' end compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC016725, BX648174

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      134918822..134959342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005227.2XP_016860716.1  cyclin-T2 isoform X1

    2. XM_017005228.3XP_016860717.1  cyclin-T2 isoform X2

    3. XM_047446260.1XP_047302216.1  cyclin-T2 isoform X4

      UniProtKB/TrEMBL
      B4DH21
    4. XM_047446259.1XP_047302215.1  cyclin-T2 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      135359158..135399741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344452.1XP_054200427.1  cyclin-T2 isoform X1

    2. XM_054344453.1XP_054200428.1  cyclin-T2 isoform X2

    3. XM_054344455.1XP_054200430.1  cyclin-T2 isoform X4

      UniProtKB/TrEMBL
      B4DH21
    4. XM_054344454.1XP_054200429.1  cyclin-T2 isoform X3