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    NNMT nicotinamide N-methyltransferase [ Homo sapiens (human) ]

    Gene ID: 4837, updated on 14-Oct-2019

    Summary

    Official Symbol
    NNMTprovided by HGNC
    Official Full Name
    nicotinamide N-methyltransferaseprovided by HGNC
    Primary source
    HGNC:HGNC:7861
    See related
    Ensembl:ENSG00000166741 MIM:600008
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver (RPKM 188.3), appendix (RPKM 69.3) and 10 other tissues See more
    Orthologs

    Genomic context

    See NNMT in Genome Data Viewer
    Location:
    11q23.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (114257806..114313536)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (114166535..114183238)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 3A Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene uncharacterized LOC101928875 Neighboring gene uncharacterized LOC101928940 Neighboring gene uncharacterized LOC107984391 Neighboring gene chromosome 11 open reading frame 71

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of nicotinamide N-methyltransferase (NNMT) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    nicotinamide N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nicotinamide N-methyltransferase activity TAS
    Traceable Author Statement
    more info
     
    pyridine N-methyltransferase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    NAD biosynthesis via nicotinamide riboside salvage pathway TAS
    Traceable Author Statement
    more info
     
    animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    methylation TAS
    Traceable Author Statement
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to organonitrogen compound IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    nicotinamide N-methyltransferase
    NP_001358974.1
    NP_001358975.1
    NP_001358976.1
    NP_006160.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372045.1NP_001358974.1  nicotinamide N-methyltransferase

      Status: REVIEWED

      Source sequence(s)
      AP002518
    2. NM_001372046.1NP_001358975.1  nicotinamide N-methyltransferase

      Status: REVIEWED

      Source sequence(s)
      AP002518
    3. NM_001372047.1NP_001358976.1  nicotinamide N-methyltransferase

      Status: REVIEWED

      Source sequence(s)
      AP002518
      Related
      ENSP00000441434.1, ENST00000535401.5
    4. NM_006169.3NP_006160.1  nicotinamide N-methyltransferase

      See identical proteins and their annotated locations for NP_006160.1

      Status: REVIEWED

      Source sequence(s)
      AP002518
      Consensus CDS
      CCDS8368.1
      UniProtKB/Swiss-Prot
      P40261
      UniProtKB/TrEMBL
      Q6FH49
      Related
      ENSP00000299964.3, ENST00000299964.3
      Conserved Domains (1) summary
      pfam01234
      Location:2259
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    RNA

    1. NR_164073.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP002518

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      114257806..114313536
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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