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    ZNF274 zinc finger protein 274 [ Homo sapiens (human) ]

    Gene ID: 10782, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF274provided by HGNC
    Official Full Name
    zinc finger protein 274provided by HGNC
    Primary source
    HGNC:HGNC:13068
    See related
    Ensembl:ENSG00000171606 MIM:605467; AllianceGenome:HGNC:13068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZF2; HFB101; ZSCAN51; ZKSCAN19
    Summary
    This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.7), ovary (RPKM 7.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF274 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58183061..58213562)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61276790..61310024)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58694428..58724928)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15178 Neighboring gene uncharacterized LOC124904784 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58694039-58694752 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58694753-58695464 Neighboring gene uncharacterized LOC105372479 Neighboring gene ribosomal protein S15a pseudogene 36 Neighboring gene zinc finger protein 436 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37843, DKFZp686K08243

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    neurotrophin receptor-interacting factor homolog
    Names
    KRAB zinc finger protein HFB101
    zinc finger protein HFB101
    zinc finger protein with KRAB and SCAN domains 19
    zinc finger protein zfp2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278734.2NP_001265663.1  neurotrophin receptor-interacting factor homolog isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (ZNF274d) has an additional segment in the 5' region, which results in a downstream translation start codon, compared to variant ZNF274c. The resulting isoform (d) has a shorter N-terminus and contains only one KRAB A domain, compared to isoform c.
      Source sequence(s)
      BC009763, CA942346, DC362701, DC366107
      Consensus CDS
      CCDS74475.1
      UniProtKB/TrEMBL
      A0A0A0MR47
      Related
      ENSP00000321209.5, ENST00000326804.8
      Conserved Domains (8) summary
      smart00431
      Location:115227
      SCAN; leucine rich region
      smart00349
      Location:245285
      KRAB; krueppel associated box
      COG5048
      Location:347599
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:523543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:549571
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:245284
      KRAB; KRAB box
      pfam02023
      Location:115203
      SCAN; SCAN domain
      pfam13465
      Location:563588
      zf-H2C2_2; Zinc-finger double domain
    2. NM_016324.4NP_057408.2  neurotrophin receptor-interacting factor homolog isoform b

      See identical proteins and their annotated locations for NP_057408.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (ZNF274b) lacks three consecutive exons in the 5' region, which results in a downstream translation start codon, compared to variant ZNF274c. The resulting isoform (b) has a shorter N-terminus and contains only one KRAB A domain, compared to isoform c.
      Source sequence(s)
      AK222855, BC009763, CA942346, DC366107
      Consensus CDS
      CCDS74476.1
      UniProtKB/Swiss-Prot
      Q96GC6
      Related
      ENSP00000409872.3, ENST00000424679.6
      Conserved Domains (6) summary
      COG5048
      Location:284536
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:460480
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:486508
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:181222
      KRAB; KRAB box
      pfam02023
      Location:52138
      SCAN; SCAN domain
      pfam13465
      Location:500525
      zf-H2C2_2; Zinc-finger double domain
    3. NM_016325.4NP_057409.1  neurotrophin receptor-interacting factor homolog isoform a

      See identical proteins and their annotated locations for NP_057409.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (ZNF274a) lacks one in-frame coding exon, compared to variant ZNF274c. The resulting isoform (a) lacks an internal segment, compared to isoform c. Like isoform c, isoform a contains two KRAB A domains.
      Source sequence(s)
      AB029150, CA942346, DC366107
      Consensus CDS
      CCDS74474.1
      UniProtKB/Swiss-Prot
      Q96GC6
      Related
      ENSP00000321187.5, ENST00000345813.7
      Conserved Domains (8) summary
      smart00431
      Location:125237
      SCAN; leucine rich region
      smart00349
      Location:255295
      KRAB; krueppel associated box
      COG5048
      Location:357612
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:533553
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:559581
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam02023
      Location:125213
      SCAN; SCAN domain
      pfam13465
      Location:573598
      zf-H2C2_2; Zinc-finger double domain
    4. NM_133502.3NP_598009.1  neurotrophin receptor-interacting factor homolog isoform c

      See identical proteins and their annotated locations for NP_598009.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (ZNF274c) encodes the longest isoform (c). Isoform c contains two KRAB A domains.
      Source sequence(s)
      AB029150, BC009763, CA942346, DC366107
      Consensus CDS
      CCDS74473.1
      UniProtKB/Swiss-Prot
      Q53XU4, Q6MZG1, Q8WY37, Q8WY38, Q92969, Q96GC6, Q9UII0, Q9UII1
      Related
      ENSP00000484810.1, ENST00000617501.5
      Conserved Domains (8) summary
      smart00431
      Location:157269
      SCAN; leucine rich region
      smart00349
      Location:1473
      KRAB; krueppel associated box
      COG5048
      Location:389644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:565585
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:591613
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:1453
      KRAB; KRAB box
      pfam02023
      Location:157245
      SCAN; SCAN domain
      pfam13465
      Location:605630
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58183061..58213562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438078.1XP_047294034.1  neurotrophin receptor-interacting factor homolog isoform X4

      UniProtKB/TrEMBL
      B4DMH6
    2. XM_011526327.2XP_011524629.1  neurotrophin receptor-interacting factor homolog isoform X2

      See identical proteins and their annotated locations for XP_011524629.1

      UniProtKB/Swiss-Prot
      Q96GC6
      Conserved Domains (6) summary
      COG5048
      Location:284536
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:460480
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:486508
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:181222
      KRAB; KRAB box
      pfam02023
      Location:52138
      SCAN; SCAN domain
      pfam13465
      Location:500525
      zf-H2C2_2; Zinc-finger double domain
    3. XM_047438076.1XP_047294032.1  neurotrophin receptor-interacting factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q53XU4, Q6MZG1, Q8WY37, Q8WY38, Q92969, Q96GC6, Q9UII0, Q9UII1
    4. XM_017026175.2XP_016881664.1  neurotrophin receptor-interacting factor homolog isoform X4

      UniProtKB/TrEMBL
      B4DMH6
    5. XM_047438075.1XP_047294031.1  neurotrophin receptor-interacting factor homolog isoform X1

      UniProtKB/Swiss-Prot
      Q53XU4, Q6MZG1, Q8WY37, Q8WY38, Q92969, Q96GC6, Q9UII0, Q9UII1
      Related
      ENSP00000478533.1, ENST00000610905.4
    6. XM_047438077.1XP_047294033.1  neurotrophin receptor-interacting factor homolog isoform X2

    7. XM_011526328.3XP_011524630.1  neurotrophin receptor-interacting factor homolog isoform X3

      See identical proteins and their annotated locations for XP_011524630.1

      Conserved Domains (3) summary
      sd00017
      Location:250270
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:276298
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:290315
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_007066543.1 RNA Sequence

    2. XR_001753589.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61276790..61310024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319567.1XP_054175542.1  neurotrophin receptor-interacting factor homolog isoform X1

    2. XM_054319572.1XP_054175547.1  neurotrophin receptor-interacting factor homolog isoform X4

      UniProtKB/TrEMBL
      B4DMH6
    3. XM_054319569.1XP_054175544.1  neurotrophin receptor-interacting factor homolog isoform X2

    4. XM_054319568.1XP_054175543.1  neurotrophin receptor-interacting factor homolog isoform X1

    5. XM_054319570.1XP_054175545.1  neurotrophin receptor-interacting factor homolog isoform X2

    6. XM_054319571.1XP_054175546.1  neurotrophin receptor-interacting factor homolog isoform X3

    RNA

    1. XR_008485067.1 RNA Sequence

    2. XR_008485068.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001278735.1: Suppressed sequence

      Description
      NM_001278735.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.