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    ZNF263 zinc finger protein 263 [ Homo sapiens (human) ]

    Gene ID: 10127, updated on 17-Jun-2024

    Summary

    Official Symbol
    ZNF263provided by HGNC
    Official Full Name
    zinc finger protein 263provided by HGNC
    Primary source
    HGNC:HGNC:13056
    See related
    Ensembl:ENSG00000006194 MIM:604191; AllianceGenome:HGNC:13056
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FPM315; ZSCAN44; ZKSCAN12
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary (RPKM 7.9), testis (RPKM 7.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF263 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3283491..3301401)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3290853..3328457)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3333491..3341460)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:3293322-3294521 Neighboring gene MEFV innate immunity regulator, pyrin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10318 Neighboring gene long intergenic non-protein coding RNA 921 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3332464-3332969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10319 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7131 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3333980-3334483 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3354991-3355520 Neighboring gene tigger transposable element derived 7 Neighboring gene zinc finger protein 75A Neighboring gene RPL7L1 pseudogene 19 Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:3414288-3415487 Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-CO2 pseudogene 28

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 263
    Names
    zinc finger protein FPM315
    zinc finger protein with KRAB and SCAN domains 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411015.1NP_001397944.1  zinc finger protein 263 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004232
      Consensus CDS
      CCDS92094.1
      UniProtKB/TrEMBL
      D3DUC1, I3L4C4, I3L538
      Related
      ENSP00000461755.2, ENST00000574674.2
    2. NM_005741.5NP_005732.2  zinc finger protein 263 isoform 1

      See identical proteins and their annotated locations for NP_005732.2

      Status: VALIDATED

      Source sequence(s)
      AK312421, BC008805
      Consensus CDS
      CCDS10499.1
      UniProtKB/Swiss-Prot
      B2R634, O14978, O43387, Q96H95
      Related
      ENSP00000219069.5, ENST00000219069.6
      Conserved Domains (6) summary
      smart00431
      Location:38149
      SCAN; leucine rich region
      smart00349
      Location:218277
      KRAB; krueppel associated box
      COG5048
      Location:434649
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:380400
      zf-C2H2; Zinc finger, C2H2 type
      pfam15498
      Location:128347
      Dendrin; Nephrin and CD2AP-binding protein, Dendrin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      3283491..3301401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3290853..3328457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379359.1XP_054235334.1  zinc finger protein 263 isoform X1

      UniProtKB/Swiss-Prot
      B2R634, O14978, O43387, Q96H95
    2. XM_054379360.1XP_054235335.1  zinc finger protein 263 isoform X1

      UniProtKB/Swiss-Prot
      B2R634, O14978, O43387, Q96H95
    3. XM_054379362.1XP_054235337.1  zinc finger protein 263 isoform X3

    4. XM_054379367.1XP_054235342.1  zinc finger protein 263 isoform X8

    5. XM_054379365.1XP_054235340.1  zinc finger protein 263 isoform X6

    6. XM_054379366.1XP_054235341.1  zinc finger protein 263 isoform X7

      UniProtKB/TrEMBL
      I3NI39
    7. XM_054379368.1XP_054235343.1  zinc finger protein 263 isoform X9

    8. XM_054379361.1XP_054235336.1  zinc finger protein 263 isoform X2

    9. XM_054379364.1XP_054235339.1  zinc finger protein 263 isoform X5

    10. XM_054379371.1XP_054235346.1  zinc finger protein 263 isoform X11

    11. XM_054379363.1XP_054235338.1  zinc finger protein 263 isoform X4

    12. XM_054379369.1XP_054235344.1  zinc finger protein 263 isoform X10

    13. XM_054379370.1XP_054235345.1  zinc finger protein 263 isoform X10