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    MAPKAP1 mitogen-activated protein kinase associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 79109, updated on 7-May-2017
    Official Symbol
    MAPKAP1provided by HGNC
    Official Full Name
    mitogen-activated protein kinase associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:18752
    See related
    Ensembl:ENSG00000119487 MIM:610558; Vega:OTTHUMG00000020683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIP1; SIN1; JC310; SIN1b; SIN1g
    Summary
    This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    9q33.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (125437394..125707234, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (128199673..128469513, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929014 Neighboring gene RNA, U5B small nuclear 5, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 30, pseudogene Neighboring gene uncharacterized LOC102723468 Neighboring gene uncharacterized LOC105376272 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 15 Neighboring gene uncharacterized LOC107987128 Neighboring gene uncharacterized LOC51145 Neighboring gene uncharacterized LOC107984127 Neighboring gene PBX homeobox 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
      Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
    • CD28 co-stimulation, organism-specific biosystem (from REACTOME)
      CD28 co-stimulation, organism-specific biosystemIn naive T cells, CD28 costimulation enhances cell cycle entry, potently stimulates expression of both the mitogenic lymphokine interleukin-2 (IL-2) and its receptor, and stimulates the activation o...
    • CD28 dependent PI3K/Akt signaling, organism-specific biosystem (from REACTOME)
      CD28 dependent PI3K/Akt signaling, organism-specific biosystemPI3Ks can be activated by a number of different receptors, including the TcR (T cell receptor), co-stimulatory receptors (CD28), cytokine receptors and chemokine receptors. However, the specific role...
    • CXCR3-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR3-mediated signaling events, organism-specific biosystem
      CXCR3-mediated signaling events
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Class I PI3K signaling events mediated by Akt, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events mediated by Akt, organism-specific biosystem
      Class I PI3K signaling events mediated by Akt
    • Constitutive Signaling by AKT1 E17K in Cancer, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by AKT1 E17K in Cancer, organism-specific biosystemWhile AKT1 gene copy number, expression level and phosphorylation are often increased in cancer, only one low frequency point mutation has been repeatedly reported in cancer and functionally studied....
    • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
      Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
    • DAP12 interactions, organism-specific biosystem (from REACTOME)
      DAP12 interactions, organism-specific biosystemDNAX activation protein of 12kDa (DAP12) is an immunoreceptor tyrosine-based activation motif (ITAM)-bearing adapter molecule that transduces activating signals in natural killer (NK) and myeloid cel...
    • DAP12 signaling, organism-specific biosystem (from REACTOME)
      DAP12 signaling, organism-specific biosystemIn response to receptor ligation, the tyrosine residues in DAP12's immunoreceptor tyrosine-based activation motif (ITAM) are phosphorylated by Src family kinases. These phosphotyrosines form the dock...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • Downstream signal transduction, organism-specific biosystem (from REACTOME)
      Downstream signal transduction, organism-specific biosystemThe role of autophosphorylation sites on PDGF receptors are to provide docking sites for downstream signal transduction molecules which contain SH2 domains. The SH2 domain is a conserved motif of aro...
    • Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
      ErbB1 downstream signaling, organism-specific biosystem
      ErbB1 downstream signaling
    • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
      Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
    • GAB1 signalosome, organism-specific biosystem (from REACTOME)
      GAB1 signalosome, organism-specific biosystemGAB1 is recruited to the activated EGFR indirectly, through GRB2. GAB1 acts as an adaptor protein that enables formation of an active PIK3, through recruitment of PIK3 regulatory subunit PIK3R1 (also...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Interferon type I signaling pathways, organism-specific biosystem (from WikiPathways)
      Interferon type I signaling pathways, organism-specific biosystemThe type I IFNs (IFN? family, IFN?, IFN?, IFN? and IFN?) all bind to and signal via the type I IFN receptor complex. The type I receptor consists of two main IFNAR1, IFNAR2c receptor chains and other...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
      PI3K/AKT Signaling in Cancer, organism-specific biosystemClass IA PI3K is a heterodimer of a p85 regulatory subunit (encoded by PIK3R1, PIK3R2 or PIK3R3) and a p110 catalytic subunit (encoded by PIK3CA, PIK3CB or PIK3CD). In the absence of activating signa...
    • PI3K/AKT activation, organism-specific biosystem (from REACTOME)
      PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
      PIP3 activates AKT signaling, organism-specific biosystemSignaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimula...
    • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
    • Regulation of TP53 Degradation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Degradation, organism-specific biosystemIn unstressed cells, TP53 (p53) has a short half-life as it undergoes rapid ubiquitination and proteasome-mediated degradation. The E3 ubiquitin ligase MDM2, which is a transcriptional target of TP53...
    • Regulation of TP53 Expression and Degradation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Expression and Degradation, organism-specific biosystemTP53 (p53) tumor suppressor protein is a transcription factor that functions as a homotetramer (Jeffrey et al. 1995). The protein levels of TP53 are low in unstressed cells due to MDM2-mediated ubiqu...
    • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
      Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • Target Of Rapamycin (TOR) Signaling, organism-specific biosystem (from WikiPathways)
      Target Of Rapamycin (TOR) Signaling, organism-specific biosystemTOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central r...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated vascular permeability, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated vascular permeability, organism-specific biosystemThe free radical nitric oxide (NO), produced by endothelial NO synthase (eNOS), is an important vasoactive substance in normal vascular biology and pathophysiology. It plays an important role in vasc...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC2745

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Ras GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-3,4,5-trisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-3,4-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell costimulation TAS
    Traceable Author Statement
    more info
     
    TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    establishment or maintenance of actin cytoskeleton polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
     
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    substantia nigra development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    target of rapamycin complex 2 subunit MAPKAP1
    Names
    MEKK2-interacting protein 1
    SAPK-interacting protein 1
    TORC2 subunit MAPKAP1
    mSIN1
    mitogen-activated protein kinase 2-associated protein 1
    ras inhibitor MGC2745
    stress-activated map kinase interacting protein 1
    stress-activated protein kinase-interacting 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006617.1NP_001006618.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 1

      See identical proteins and their annotated locations for NP_001006618.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as Sin1 and Mip1b, represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL833042, AY524429, BX438260
      Consensus CDS
      CCDS35140.1
      UniProtKB/Swiss-Prot
      Q9BPZ7
      Related
      ENSP00000265960.3, ENST00000265960.7
      Conserved Domains (3) summary
      cd13331
      Location:383490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    2. NM_001006618.1NP_001006619.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 5

      See identical proteins and their annotated locations for NP_001006619.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as Sin1a, differs in the 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 5), also known as the alpha isoform, has a shorter and distinct C-terminus, compared to isoform 1. The existence of this isoform has not been confirmed experimentally.
      Source sequence(s)
      AY524429, AY524430, BX438260
      Consensus CDS
      CCDS48020.1
      UniProtKB/Swiss-Prot
      Q9BPZ7
      Related
      ENSP00000377624.3, OTTHUMP00000022135, ENST00000394060.7, OTTHUMT00000054086
      Conserved Domains (2) summary
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    3. NM_001006619.1NP_001006620.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 3

      See identical proteins and their annotated locations for NP_001006620.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as Sin1g, lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 3), also known as the gamma isoform, is shorter, compared to isoform 1.
      Source sequence(s)
      AY524432, BX438260
      Consensus CDS
      CCDS35139.1
      UniProtKB/Swiss-Prot
      Q9BPZ7
      Related
      ENSP00000362610.2, OTTHUMP00000215289, ENST00000373511.6, OTTHUMT00000355308
      Conserved Domains (3) summary
      cd13331
      Location:353443
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    4. NM_001006620.1NP_001006621.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 4

      See identical proteins and their annotated locations for NP_001006621.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as Sin1d, lacks an alternate in-frame exon in the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 4), also known as the delta isoform, has a shorter N-terminus, compared to isoform 1. The existence of this isoform has not been confirmed experimentally. Variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      AL833042, AY524429, BX438260
      Consensus CDS
      CCDS35141.1
      UniProtKB/Swiss-Prot
      Q9BPZ7
      Related
      ENSP00000362602.3, OTTHUMP00000022140, ENST00000373503.7, OTTHUMT00000054091
      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    5. NM_001006621.1NP_001006622.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 4

      See identical proteins and their annotated locations for NP_001006622.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as Sin1e, lacks two alternate in-frame exons in the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 4), also known as the delta isoform, has a shorter N-terminus, compared to isoform 1. The existence of this isoform has not been confirmed experimentally. Variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      AL833042, AY524429, BX438260
      Consensus CDS
      CCDS35141.1
      UniProtKB/Swiss-Prot
      Q9BPZ7
      Related
      ENSP00000377627.1, ENST00000394063.5
      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    6. NM_024117.3NP_077022.1  target of rapamycin complex 2 subunit MAPKAP1 isoform 2

      See identical proteins and their annotated locations for NP_077022.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as Sin1b and Mip1a, lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2), also known as the beta isoform, is shorter, compared to isoform 1.
      Source sequence(s)
      AY524429, BC002326, BX438260
      Consensus CDS
      CCDS6864.1
      UniProtKB/Swiss-Prot
      Q9BPZ7
      UniProtKB/TrEMBL
      A0A024R863
      Related
      ENSP00000265961.5, OTTHUMP00000022139, ENST00000350766.7, OTTHUMT00000054090
      Conserved Domains (3) summary
      cd13331
      Location:347454
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      125437394..125707234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519007.1XP_011517309.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X4

      Conserved Domains (3) summary
      cd13331
      Location:400490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139313
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    2. XM_011519005.1XP_011517307.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X1

      See identical proteins and their annotated locations for XP_011517307.1

      Conserved Domains (3) summary
      cd13331
      Location:430537
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139313
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    3. XM_017015126.1XP_016870615.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X3

      UniProtKB/Swiss-Prot
      Q9BPZ7
      Related
      ENSP00000362597.1, OTTHUMP00000022141, ENST00000373498.5, OTTHUMT00000054092
      Conserved Domains (3) summary
      cd13331
      Location:383490
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    4. XM_011519006.2XP_011517308.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X2

      Conserved Domains (3) summary
      cd13331
      Location:394501
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139313
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    5. XM_017015127.1XP_016870616.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X5

      UniProtKB/Swiss-Prot
      Q9BPZ7
      UniProtKB/TrEMBL
      A0A024R863
      Conserved Domains (3) summary
      cd13331
      Location:347454
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139266
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    6. XM_011519010.2XP_011517312.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X8

      See identical proteins and their annotated locations for XP_011517312.1

      UniProtKB/Swiss-Prot
      Q9BPZ7
      Conserved Domains (2) summary
      cd13331
      Location:191298
      PH_Avo1; Avo1 Pleckstrin homology (PH) domain
      pfam16978
      Location:174
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
    7. XM_011519008.1XP_011517310.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X6

      Conserved Domains (3) summary
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139313
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
      cl17171
      Location:430451
      PH-like; Pleckstrin homology-like domain
    8. XM_011519009.1XP_011517311.1  target of rapamycin complex 2 subunit MAPKAP1 isoform X7

      Conserved Domains (2) summary
      pfam05422
      Location:18129
      SIN1; Stress-activated map kinase interacting protein 1 (SIN1)
      pfam16978
      Location:139313
      CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      128349298..128620475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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