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    PLD1 phospholipase D1 [ Homo sapiens (human) ]

    Gene ID: 5337, updated on 7-Jul-2019

    Summary

    Official Symbol
    PLD1provided by HGNC
    Official Full Name
    phospholipase D1provided by HGNC
    Primary source
    HGNC:HGNC:9067
    See related
    Ensembl:ENSG00000075651 MIM:602382
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CVDD
    Summary
    This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in gall bladder (RPKM 28.0), duodenum (RPKM 12.6) and 24 other tissues See more
    Orthologs

    Genomic context

    See PLD1 in Genome Data Viewer
    Location:
    3q26.31
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (171600404..171810483, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (171318195..171528284, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724479 Neighboring gene RNA, U6 small nuclear 348, pseudogene Neighboring gene transmembrane protein 212 Neighboring gene TMEM212 antisense RNA 1 Neighboring gene uncharacterized LOC105374218

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 replication requires PLD1 as shown through specific PLD1 inhibitors in activated CD4+ T cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced phosphatidylcholine-specific phospholipase D (PLD) activity is dependent on the activation of ERK1/2 PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of phosphatidylcholine-specific phospholipase D1 (PLD1) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Alpha-synuclein signaling, organism-specific biosystem (from Pathway Interaction Database)
      Alpha-synuclein signaling, organism-specific biosystem
      Alpha-synuclein signaling
    • Arf6 downstream pathway, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 downstream pathway, organism-specific biosystem
      Arf6 downstream pathway
    • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
      Arf6 trafficking events, organism-specific biosystem
      Arf6 trafficking events
    • CDC42 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CDC42 signaling events, organism-specific biosystem
      CDC42 signaling events
    • Choline metabolism in cancer, organism-specific biosystem (from KEGG)
      Choline metabolism in cancer, organism-specific biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
    • Choline metabolism in cancer, conserved biosystem (from KEGG)
      Choline metabolism in cancer, conserved biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
      ErbB1 downstream signaling, organism-specific biosystem
      ErbB1 downstream signaling
    • Ether lipid metabolism, organism-specific biosystem (from KEGG)
      Ether lipid metabolism, organism-specific biosystem
      Ether lipid metabolism
    • Ether lipid metabolism, conserved biosystem (from KEGG)
      Ether lipid metabolism, conserved biosystem
      Ether lipid metabolism
    • Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystem (from WikiPathways)
      Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, organism-specific biosystemThe signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth...
    • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
      Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glycerophospholipid biosynthesis, organism-specific biosystem (from REACTOME)
      Glycerophospholipid biosynthesis, organism-specific biosystemGlycerophospholipids are important structural and functional components of biological membranes and constituents of serum lipoproteins and the pulmonary surfactant. In addition, glycerophospholipids...
    • Glycerophospholipid metabolism, organism-specific biosystem (from KEGG)
      Glycerophospholipid metabolism, organism-specific biosystem
      Glycerophospholipid metabolism
    • Glycerophospholipid metabolism, conserved biosystem (from KEGG)
      Glycerophospholipid metabolism, conserved biosystem
      Glycerophospholipid metabolism
    • GnRH signaling pathway, organism-specific biosystem (from KEGG)
      GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • GnRH signaling pathway, conserved biosystem (from KEGG)
      GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
    • Human Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystem (from WikiPathways)
      Human Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-th...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
      Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
      Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
    • Phospholipid metabolism, organism-specific biosystem (from REACTOME)
      Phospholipid metabolism, organism-specific biosystemPhospholipids contain a polar head group and two long-chain fatty acyl moieties, one of which is generally unsaturated. The head group is a glycerol or serine phosphate attached to a polar group such...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Role of phospholipids in phagocytosis, organism-specific biosystem (from REACTOME)
      Role of phospholipids in phagocytosis, organism-specific biosystemPhospholipases play an integral role in phagocytosis by generating essential second messengers. An early step in phagocytic signaling is the association of PIP2 and IP3 with the phagocytic cup. These...
    • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
      Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
    • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
      Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
    • Synthesis of PA, organism-specific biosystem (from REACTOME)
      Synthesis of PA, organism-specific biosystemIn the de novo synthesis of phosphatidic acid (PA), lysophosphatidic acid (LPA) is initially formed by the esterification of sn-1 by glycerol 3-phosphate acyltransferase (GPAT) from glycerol 3-phosph...
    • Synthesis of PG, organism-specific biosystem (from REACTOME)
      Synthesis of PG, organism-specific biosystemPhosphatidylglycerol (PG) is synthesised at the inner mitochondrial (IM) membrane, phosphatidic acid (PA) and cytidine triphosphate (CTP) are converted into cytidine diphosphate-diacylglycerol (CDP-D...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • phospholipases, organism-specific biosystem (from BIOCYC)
      phospholipases, organism-specific biosystem
      phospholipases

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase D activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    inositol lipid-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
     
    regulation of microvillus assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic vesicle cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of synaptic vesicle cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cholinergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane HDA PubMed 
    membrane HDA PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    specific granule membrane TAS
    Traceable Author Statement
    more info
     
    tertiary granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    phospholipase D1
    Names
    choline phosphatase 1
    phosphatidylcholine-hydrolyzing phospholipase D1
    phospholipase D1, phosphatidylcholine-specific
    NP_001123553.1
    NP_002653.1
    XP_005247590.1
    XP_005247591.1
    XP_011511199.1
    XP_011511200.1
    XP_011511201.1
    XP_016862112.1
    XP_016862113.1
    XP_024309366.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029851.1 RefSeqGene

      Range
      5001..215090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001130081.3NP_001123553.1  phospholipase D1 isoform b

      See identical proteins and their annotated locations for NP_001123553.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The resulting isoform (b) has the same N- and C-termini, but is shorter compared to isoform a.
      Source sequence(s)
      AB209907, AC008134, DA464847
      Consensus CDS
      CCDS46957.1
      UniProtKB/TrEMBL
      Q59EA4
      Related
      ENSP00000348681.5, ENST00000356327.9
      Conserved Domains (5) summary
      cd07296
      Location:78209
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:352502
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:716897
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:821021
      PLN02866; phospholipase D
      cd01254
      Location:197326
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    2. NM_002662.5NP_002653.1  phospholipase D1 isoform a

      See identical proteins and their annotated locations for NP_002653.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB209907, AC008134, BC068976, DA464847
      Consensus CDS
      CCDS3216.1
      UniProtKB/Swiss-Prot
      Q13393
      UniProtKB/TrEMBL
      Q59EA4
      Related
      ENSP00000342793.4, ENST00000351298.9
      Conserved Domains (1) summary
      cl26365
      Location:821059
      PLN03008; Phospholipase D delta

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      171600404..171810483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247534.2XP_005247591.1  phospholipase D1 isoform X2

      See identical proteins and their annotated locations for XP_005247591.1

      UniProtKB/Swiss-Prot
      Q13393
      Conserved Domains (5) summary
      cd07296
      Location:78209
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:352502
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:716897
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      PLN02866
      Location:821021
      PLN02866; phospholipase D
      cd01254
      Location:197326
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
    2. XM_005247533.2XP_005247590.1  phospholipase D1 isoform X1

      See identical proteins and their annotated locations for XP_005247590.1

      UniProtKB/Swiss-Prot
      Q13393
      Conserved Domains (1) summary
      cl26365
      Location:821059
      PLN03008; Phospholipase D delta
    3. XM_024453598.1XP_024309366.1  phospholipase D1 isoform X6

      Conserved Domains (1) summary
      cl26365
      Location:1653
      PLN03008; Phospholipase D delta
    4. XM_011512899.2XP_011511201.1  phospholipase D1 isoform X7

      Conserved Domains (3) summary
      cd09844
      Location:337518
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      pfam13091
      Location:349520
      PLDc_2; PLD-like domain
      cl15239
      Location:185
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    5. XM_017006624.1XP_016862113.1  phospholipase D1 isoform X7

      Conserved Domains (3) summary
      cd09844
      Location:337518
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      pfam13091
      Location:349520
      PLDc_2; PLD-like domain
      cl15239
      Location:185
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins
    6. XM_011512898.1XP_011511200.1  phospholipase D1 isoform X4

      Conserved Domains (6) summary
      cd07296
      Location:78209
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:352502
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:754935
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      cd01254
      Location:197326
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
      pfam00169
      Location:222327
      PH; PH domain
      pfam13091
      Location:766937
      PLDc_2; PLD-like domain
    7. XM_017006623.2XP_016862112.1  phospholipase D1 isoform X5

    8. XM_011512897.1XP_011511199.1  phospholipase D1 isoform X3

      See identical proteins and their annotated locations for XP_011511199.1

      UniProtKB/Swiss-Prot
      Q13393
      Conserved Domains (6) summary
      cd07296
      Location:78209
      PX_PLD1; The phosphoinositide binding Phox Homology domain of Phospholipase D1
      cd09842
      Location:352502
      PLDc_vPLD1_1; Catalytic domain, repeat 1, of vertebrate phospholipase D1
      cd09844
      Location:754935
      PLDc_vPLD1_2; Catalytic domain, repeat 2, of vertebrate phospholipase D1
      cd01254
      Location:197326
      PH_PLD; Phospholipase D pleckstrin homology (PH) domain
      pfam00169
      Location:222327
      PH; PH domain
      pfam13091
      Location:766937
      PLDc_2; PLD-like domain

    RNA

    1. XR_001740174.1 RNA Sequence

    2. XR_001740175.1 RNA Sequence

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