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    HNRNPM heterogeneous nuclear ribonucleoprotein M [ Homo sapiens (human) ]

    Gene ID: 4670, updated on 14-Oct-2019

    Summary

    Official Symbol
    HNRNPMprovided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein Mprovided by HGNC
    Primary source
    HGNC:HGNC:5046
    See related
    Ensembl:ENSG00000099783 MIM:160994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEAR; HNRPM; HTGR1; NAGR1; HNRPM4; HNRNPM4; hnRNP M
    Summary
    This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 50.0), colon (RPKM 44.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See HNRNPM in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (8444575..8489114)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (8509460..8554002)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RAB11B antisense RNA 1 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene GATA motif-containing MPRA enhancer 154 Neighboring gene membrane associated ring-CH-type finger 2 Neighboring gene PML-RARA regulated adaptor molecule 1 Neighboring gene zinc finger protein 414

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Cellular biotinylated heterogeneous nuclear ribonucleoprotein M (HNRNPM) is incorporated into HIV-1 Gag virus-like particles PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein M (HNRNPM), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPM is increased by RRE PubMed
    Tat tat Heterogeneous nuclear ribonucleoprotein M (HNRNPM) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that HNRNPM gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with HNRNPM PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • FGFR2 alternative splicing, organism-specific biosystem (from REACTOME)
      FGFR2 alternative splicing, organism-specific biosystemAlternative splicing of the FGFR2 nascent mRNA generates an epithelial specific isoform (FGFR2 IIIb) and a mesenchymal specific isoform (FGFR2 IIIc). The inclusion of exon 8 in FGFR2 IIIb or exon 9 ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • mRNA Processing, organism-specific biosystem (from WikiPathways)
      mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
    • mRNA Splicing, organism-specific biosystem (from REACTOME)
      mRNA Splicing, organism-specific biosystemThe process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing...
    • mRNA Splicing - Major Pathway, organism-specific biosystem (from REACTOME)
      mRNA Splicing - Major Pathway, organism-specific biosystemThe splicing of pre-mRNA occurs within a large, very dynamic complex, designated the 'spliceosome'. The 50-60S spliceosomes are estimated to be 40-60 nm in diameter, and have molecular weights in the...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp547H118

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    RNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA metabolic process TAS
    Traceable Author Statement
    more info
     
    alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    PubMed 
    mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
     
    regulation of mRNA stability involved in response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen-containing extracellular matrix HDA PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    membrane HDA PubMed 
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    paraspeckles IDA
    Inferred from Direct Assay
    more info
    PubMed 
    post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heterogeneous nuclear ribonucleoprotein M
    Names
    CEA receptor
    N-acetylglucosamine receptor 1
    heterogenous nuclear ribonucleoprotein M4
    hnRNA-binding protein M4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029850.1 RefSeqGene

      Range
      5057..49196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297418.2NP_001284347.1  heterogeneous nuclear ribonucleoprotein M isoform c

      See identical proteins and their annotated locations for NP_001284347.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AA244120, AB209733, CN350481, CN350526, HY007201
      UniProtKB/TrEMBL
      Q59ES8
      Conserved Domains (4) summary
      cd12386
      Location:86159
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12661
      Location:519595
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cl17169
      Location:127
      RRM_SF; RNA recognition motif (RRM) superfamily
      cl25887
      Location:82236
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    2. NM_005968.5NP_005959.2  heterogeneous nuclear ribonucleoprotein M isoform a

      See identical proteins and their annotated locations for NP_005959.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC000138, CN350526
      Consensus CDS
      CCDS12203.1
      UniProtKB/Swiss-Prot
      P52272
      Related
      ENSP00000325376.2, ENST00000325495.9
      Conserved Domains (5) summary
      cd12386
      Location:206279
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12657
      Location:72147
      RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:654730
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam09606
      Location:385603
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam11532
      Location:4270
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    3. NM_031203.4NP_112480.2  heterogeneous nuclear ribonucleoprotein M isoform b

      See identical proteins and their annotated locations for NP_112480.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      BC008895, BC058893, CN350526, DB478004
      Consensus CDS
      CCDS12204.1
      UniProtKB/Swiss-Prot
      P52272
      Related
      ENSP00000325732.2, ENST00000348943.7
      Conserved Domains (5) summary
      cd12386
      Location:167240
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12661
      Location:615691
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam09606
      Location:346564
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam11532
      Location:4270
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cl17169
      Location:72147
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      8444575..8489114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272479.2XP_005272536.1  heterogeneous nuclear ribonucleoprotein M isoform X2

      See identical proteins and their annotated locations for XP_005272536.1

      Conserved Domains (4) summary
      cd12386
      Location:206279
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12657
      Location:72147
      RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:636712
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:4270
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    2. XM_017026823.1XP_016882312.1  heterogeneous nuclear ribonucleoprotein M isoform X3

      Conserved Domains (5) summary
      COG0724
      Location:622697
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:206279
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12657
      Location:72147
      RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:621697
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:4170
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    3. XM_017026824.1XP_016882313.1  heterogeneous nuclear ribonucleoprotein M isoform X5

      Conserved Domains (4) summary
      cd12386
      Location:167240
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12661
      Location:597673
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:4270
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cl17169
      Location:72147
      RRM_SF; RNA recognition motif (RRM) superfamily
    4. XM_005272480.2XP_005272537.1  heterogeneous nuclear ribonucleoprotein M isoform X4

      See identical proteins and their annotated locations for XP_005272537.1

      Conserved Domains (5) summary
      COG0724
      Location:601676
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:167240
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12661
      Location:600676
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:4170
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
      cl17169
      Location:72147
      RRM_SF; RNA recognition motif (RRM) superfamily
    5. XM_017026825.1XP_016882314.1  heterogeneous nuclear ribonucleoprotein M isoform X6

    6. XM_005272481.1XP_005272538.1  heterogeneous nuclear ribonucleoprotein M isoform X7

      See identical proteins and their annotated locations for XP_005272538.1

      Conserved Domains (4) summary
      COG0724
      Location:535610
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:86159
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12661
      Location:534610
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cl17169
      Location:127
      RRM_SF; RNA recognition motif (RRM) superfamily
    7. XM_017026827.1XP_016882316.1  heterogeneous nuclear ribonucleoprotein M isoform X9

    8. XM_017026829.1XP_016882318.1  heterogeneous nuclear ribonucleoprotein M isoform X12

    9. XM_017026830.1XP_016882319.1  heterogeneous nuclear ribonucleoprotein M isoform X13

    10. XM_005272483.2XP_005272540.1  heterogeneous nuclear ribonucleoprotein M isoform X10

      See identical proteins and their annotated locations for XP_005272540.1

      Conserved Domains (4) summary
      COG0724
      Location:496571
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:47120
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12661
      Location:495571
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cl17169
      Location:127
      RRM_SF; RNA recognition motif (RRM) superfamily
    11. XM_005272478.3XP_005272535.1  heterogeneous nuclear ribonucleoprotein M isoform X1

      See identical proteins and their annotated locations for XP_005272535.1

      Conserved Domains (5) summary
      COG0724
      Location:640715
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:206279
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12657
      Location:72147
      RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      cd12661
      Location:639715
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
      pfam11532
      Location:4170
      HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
    12. XM_017026828.1XP_016882317.1  heterogeneous nuclear ribonucleoprotein M isoform X11

      Conserved Domains (3) summary
      TIGR01628
      Location:3197
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:47120
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12661
      Location:480556
      RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)
    13. XM_017026826.1XP_016882315.1  heterogeneous nuclear ribonucleoprotein M isoform X8

    14. XM_017026831.1XP_016882320.1  heterogeneous nuclear ribonucleoprotein M isoform X14

    15. XM_017026832.1XP_016882321.1  heterogeneous nuclear ribonucleoprotein M isoform X15

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