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    IL22RA2 interleukin 22 receptor subunit alpha 2 [ Homo sapiens (human) ]

    Gene ID: 116379, updated on 17-Jun-2019

    Summary

    Official Symbol
    IL22RA2provided by HGNC
    Official Full Name
    interleukin 22 receptor subunit alpha 2provided by HGNC
    Primary source
    HGNC:HGNC:14901
    See related
    Ensembl:ENSG00000164485 MIM:606648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
    Summary
    This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See IL22RA2 in Genome Data Viewer
    Location:
    6q23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (137143820..137173644, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137464957..137494785, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene neuroblastoma highly expressed 1 Neighboring gene interleukin 20 receptor subunit alpha Neighboring gene interferon gamma receptor 1 Neighboring gene uncharacterized LOC105378017

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-19, 20, 22, 24, organism-specific biosystem (from REACTOME)
      Interleukin-19, 20, 22, 24, organism-specific biosystemThe interleukin-20 (IL20) subfamily comprises IL19, IL-20, IL-22, IL-24 and IL-26. They are members of the larger IL-10 family, but have been grouped together based on their usage of common receptor ...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC150509, MGC150510

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    interleukin-22 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-22 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    interleukin-22 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of tyrosine phosphorylation of STAT protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    interleukin-22 receptor subunit alpha-2
    Names
    cytokine receptor class-II member 10
    cytokine receptor family type 2, soluble 1
    interleukin 22 receptor, alpha 2
    interleukin 22-binding protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052962.3NP_443194.1  interleukin-22 receptor subunit alpha-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_443194.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI824338, AJ313162, AY040566
      Consensus CDS
      CCDS5182.1
      UniProtKB/Swiss-Prot
      Q969J5
      Related
      ENSP00000296980.2, ENST00000296980.6
      Conserved Domains (2) summary
      pfam01108
      Location:24146
      Tissue_fac; Tissue factor
      pfam09294
      Location:158263
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    2. NM_181309.2NP_851826.1  interleukin-22 receptor subunit alpha-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_851826.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AI824338, AJ313161, AY040566
      Consensus CDS
      CCDS5183.1
      UniProtKB/Swiss-Prot
      Q969J5
      Related
      ENSP00000296979.4, ENST00000349184.8
      Conserved Domains (2) summary
      pfam01108
      Location:23114
      Tissue_fac; Tissue factor
      pfam09294
      Location:126231
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
    3. NM_181310.2NP_851827.1  interleukin-22 receptor subunit alpha-2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_851827.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons in the coding region, which leads to a translation frameshift, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI824338, AJ313161, AY040568
      Consensus CDS
      CCDS5184.1
      UniProtKB/Swiss-Prot
      Q969J5
      Related
      ENSP00000340920.3, ENST00000339602.3
      Conserved Domains (1) summary
      pfam01108
      Location:24114
      Tissue_fac; Tissue factor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      137143820..137173644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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