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    CHUK component of inhibitor of nuclear factor kappa B kinase complex [ Homo sapiens (human) ]

    Gene ID: 1147, updated on 13-Jan-2020

    Summary

    Official Symbol
    CHUKprovided by HGNC
    Official Full Name
    component of inhibitor of nuclear factor kappa B kinase complexprovided by HGNC
    Primary source
    HGNC:HGNC:1974
    See related
    Ensembl:ENSG00000213341 MIM:600664
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha
    Summary
    This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 4.9), bone marrow (RPKM 4.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See CHUK in Genome Data Viewer
    Location:
    10q24.31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (100188298..100229610, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (101948123..101989367, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene signal peptidase complex subunit 2 pseudogene 2 Neighboring gene ER lipid raft associated 1 Neighboring gene CWF19 like cell cycle control factor 1 Neighboring gene small nucleolar RNA, H/ACA box 12 Neighboring gene prohibitin pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Cocoon syndrome
    MedGen: C3150891 OMIM: 613630 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120/CD4 interaction-induced NF-kappaB activation stimulates the hyperphosphorylation of IkappaB-alpha by IkappaB kinases (IKKs) PubMed
    Nef nef HIV-1 Nef induces phosphorylation of CHUK (IKKalpha) PubMed
    nef HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 PubMed
    nef HIV-1 Nef induces phosphorylation of IKKalpha in M2-type macrophages PubMed
    nef The interaction of HIV-1 Nef with TRAF2, TRAF5, and TRAF6 proteins activates NF-kappaB, leading to the degradation of IkappaB-alpha and the increased phosphorylation of IKK-alpha and IKK-beta in monocyte-derived macrophages PubMed
    nef HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members PubMed
    Tat tat HIV-1 Tat induces phosphorylation of CHUK (IKKalpha) in CRT-MG human astroglioma cells PubMed
    tat HIV-1 Tat induces phosphorylation of IKK-alpha/IKK-beta in human astroglioma cells PubMed
    tat HIV-1 Tat induces phosphorylation of IKK in HeLa-CD4-long terminal repeat (LTR)-beta-gal (MAGI) cells PubMed
    tat Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) PubMed
    tat Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 PubMed
    Vpr vpr HIV-1 Vpr requires CHUK (IKKa) or IKBKB (IKKb) to induce G2/M arrest in HeLa cells as shown through siRNA knockdown of CHUK (IKKa) or IKBKB (IKKb) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to IkappaB kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    IkappaB kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    scaffold protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    I-kappaB kinase/NF-kappaB signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    I-kappaB phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    MyD88-independent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    NIK/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NIK/NF-kappaB signaling TAS
    Traceable Author Statement
    more info
     
    Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    TRIF-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
    Traceable Author Statement
    more info
     
    cellular response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-1-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
    Traceable Author Statement
    more info
     
    positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of interferon-alpha secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    response to acetate IEA
    Inferred from Electronic Annotation
    more info
     
    response to amino acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to cholecystokinin IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to hydroperoxide IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    skeletal muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    stress-activated MAPK cascade TAS
    Traceable Author Statement
    more info
     
    striated muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    CD40 receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    IkappaB kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    IkappaB kinase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    inhibitor of nuclear factor kappa-B kinase subunit alpha
    Names
    I-kappa-B kinase 1
    I-kappa-B kinase-alpha
    IKK-a kinase
    IkB kinase alpha subunit
    Nuclear factor NFkappaB inhibitor kinase alpha
    TCF-16
    conserved helix-loop-helix ubiquitous kinase
    transcription factor 16
    NP_001269.3
    NP_001307857.1
    XP_016871100.1
    XP_016871101.1
    XP_016871102.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028023.1 RefSeqGene

      Range
      4992..46288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001278.5NP_001269.3  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_001269.3

      Status: REVIEWED

      Source sequence(s)
      AF080157, AI829429, BC034796, BM800404, DA405845
      Consensus CDS
      CCDS7488.1
      UniProtKB/Swiss-Prot
      O15111
      Related
      ENSP00000359424.6, ENST00000370397.8
      Conserved Domains (2) summary
      cd14039
      Location:21309
      STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha
      pfam12179
      Location:709743
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
    2. NM_001320928.1NP_001307857.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 2

      Status: REVIEWED

      Source sequence(s)
      AI829429, AL138921, DA405845
      Conserved Domains (2) summary
      smart00220
      Location:15298
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14039
      Location:21309
      STKc_IKK_alpha; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      100188298..100229610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015611.1XP_016871100.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1

    2. XM_017015613.1XP_016871102.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3

    3. XM_017015612.1XP_016871101.1  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2

    RNA

    1. XR_001747011.1 RNA Sequence

    2. XR_001747010.1 RNA Sequence

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