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    Pola2 DNA polymerase alpha 2, accessory subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85242, updated on 21-Jul-2018

    Summary

    Official Symbol
    Pola2provided by RGD
    Official Full Name
    DNA polymerase alpha 2, accessory subunitprovided by RGD
    Primary source
    RGD:621817
    See related
    Ensembl:ENSRNOG00000020906
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    plays a role in DNA replication [RGD, Feb 2006]
    Expression
    Biased expression in Heart (RPKM 81.3), Thymus (RPKM 73.3) and 9 other tissues See more
    Orthologs

    Genomic context

    See Pola2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221297417..221321601, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (228231866..228255908, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene CDC42 effector protein 2 Neighboring gene 40S ribosomal protein S27-like Neighboring gene solute carrier family 22, member 20 Neighboring gene calpain 1 Neighboring gene uncharacterized LOC108349685

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-directed DNA polymerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein import into nucleus, translocation IEA
    Inferred from Electronic Annotation
    more info
     
    protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    alpha DNA polymerase:primase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    alpha DNA polymerase:primase complex IC
    Inferred by Curator
    more info
    PubMed 
    alpha DNA polymerase:primase complex IEA
    Inferred from Electronic Annotation
    more info
     
    alpha DNA polymerase:primase complex ISO
    Inferred from Sequence Orthology
    more info
     
    alpha DNA polymerase:primase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA polymerase alpha subunit B
    Names
    DNA polymerase alpha 70 kDa subunit
    DNA polymerase alpha subunit II
    DNA polymerase subunit II
    DNA-directed DNA polymerase alpha 2
    polymerase (DNA directed), alpha 2, accessory subunit
    polymerase (DNA) alpha 2, accessory subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053480.2NP_445932.2  DNA polymerase alpha subunit B

      See identical proteins and their annotated locations for NP_445932.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097300
      UniProtKB/TrEMBL
      Q4V8M9
      Related
      ENSRNOP00000028406.3, ENSRNOT00000028406.4
      Conserved Domains (2) summary
      pfam04042
      Location:343549
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam08418
      Location:20238
      Pol_alpha_B_N; DNA polymerase alpha subunit B N-terminal

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      221297417..221321601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001835495.1 RNA Sequence

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      200761869..200785913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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