Format

Send to:

Choose Destination
    • Showing Current items.

    YCF1 ATP-binding cassette glutathione S-conjugate transporter YCF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851713, updated on 9-Sep-2018

    Summary

    Gene symbol
    YCF1
    Gene description
    ATP-binding cassette glutathione S-conjugate transporter YCF1
    Primary source
    SGD:S000002542
    Locus tag
    YDR135C
    Gene type
    protein coding
    RNA name
    ATP-binding cassette glutathione S-conjugate transporter YCF1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

    Genomic context

    See YCF1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (723004..727551, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene pseudo Neighboring gene Rgp1p Neighboring gene Hpr1p

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity, coupled to transmembrane movement of substances IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity, coupled to transmembrane movement of substances IEA
    Inferred from Electronic Annotation
    more info
     
    bilirubin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    bilirubin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione S-conjugate-exporting ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    bilirubin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to cadmium ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to metal ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    fungal-type vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fungal-type vacuole membrane HDA PubMed 
    fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
     
    vacuole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ATP-binding cassette glutathione S-conjugate transporter YCF1
    NP_010419.3
    • Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      723004..727551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180442.3NP_010419.3  TPA: ATP-binding cassette glutathione S-conjugate transporter YCF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010419.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P39109
      Conserved Domains (4) summary
      TIGR00957
      Location:271511
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:12701491
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:631830
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:292578
      ABC_membrane; ABC transporter transmembrane region
    Support Center