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    IDH2 isocitrate dehydrogenase subunit 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816218, updated on 5-Aug-2018

    Summary

    Gene symbol
    IDH2
    Gene description
    isocitrate dehydrogenase subunit 2
    Primary source
    Araport:AT2G17130
    Locus tag
    AT2G17130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6P23.14; F6P23_14; IDH-II; isocitrate dehydrogenase II; isocitrate dehydrogenase subunit 2; NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2
    Summary
    Encodes a regulatory subunit of the mitochondrially-localized NAD+- dependent isocitrate dehydrogenase.

    Genomic context

    See IDH2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    4
    Sequence:
    Chromosome: 2; NC_003071.7 (7460814..7462607, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase subunit beta, putative (DUF630 and DUF632) Neighboring gene hypothetical protein Neighboring gene lysm domain GPI-anchored protein 2 precursor Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Plant regulator RWP-RK family protein Neighboring gene Interleukin-1 receptor-associated kinase 4 protein

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    NM_127267.3
    NM_179632.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    isocitrate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    isocitrate dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    isocitrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
     
    tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISM
    Inferred from Sequence Model
    more info
     

    General protein information

    Preferred Names
    isocitrate dehydrogenase subunit 2
    NP_179304.1
    • isocitrate dehydrogenase subunit 2 (IDH2); FUNCTIONS IN: isocitrate dehydrogenase (NAD+) activity; INVOLVED IN: isocitrate metabolic process, tricarboxylic acid cycle, metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Isocitrate/isopropylmalate dehydrogenase (InterPro:IPR001804), Isocitrate dehydrogenase NAD-dependent, mitochondrial (InterPro:IPR004434); BEST Arabidopsis thaliana protein match is: isocitrate dehydrogenase 1 (TAIR:AT4G35260.1); Has 16085 Blast hits to 15952 proteins in 2729 species: Archae - 398; Bacteria - 9705; Metazoa - 617; Fungi - 814; Plants - 241; Viruses - 0; Other Eukaryotes - 4310 (source: NCBI BLink).
    NP_849963.1
    • isocitrate dehydrogenase subunit 2 (IDH2); FUNCTIONS IN: isocitrate dehydrogenase (NAD+) activity; INVOLVED IN: isocitrate metabolic process, tricarboxylic acid cycle, metabolic process; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Isocitrate/isopropylmalate dehydrogenase (InterPro:IPR001804), Isocitrate dehydrogenase NAD-dependent, mitochondrial (InterPro:IPR004434); BEST Arabidopsis thaliana protein match is: isocitrate dehydrogenase 1 (TAIR:AT4G35260.1); Has 15958 Blast hits to 15829 proteins in 2704 species: Archae - 398; Bacteria - 9603; Metazoa - 617; Fungi - 818; Plants - 241; Viruses - 0; Other Eukaryotes - 4281 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7460814..7462607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179632.2NP_849963.1  isocitrate dehydrogenase subunit 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849963.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93032
      UniProtKB/TrEMBL
      A0A178VYB0
      Conserved Domains (1) summary
      PLN00123
      Location:8363
      PLN00123; isocitrate dehydrogenase (NAD+)
    2. NM_127267.3NP_179304.1  isocitrate dehydrogenase subunit 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179304.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93032
      UniProtKB/TrEMBL
      A0A178W0H4
      Conserved Domains (1) summary
      PLN00123
      Location:8367
      PLN00123; isocitrate dehydrogenase (NAD+)
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