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    COX2 cytochrome c oxidase subunit II [ Pan troglodytes (chimpanzee) ]

    Gene ID: 807864, updated on 23-Mar-2018

    Summary

    Gene symbol
    COX2
    Gene description
    cytochrome c oxidase subunit II
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan

    Genomic context

    See COX2 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    105 current Clint_PTRv2 (GCF_002880755.1) MT (non-nuclear) NC_001643.1 (7003..7686)
    103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) MT (non-nuclear) NC_001643.1 (7003..7686)

    Chromosome MT - NC_001643.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase subunit 2 Neighboring gene cytochrome c oxidase subunit I Neighboring gene ATP synthase F0 subunit 8 Neighboring gene ATP synthase F0 subunit 6 Neighboring gene cytochrome c oxidase subunit III

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cytochrome c oxidase, organism-specific biosystem (from KEGG)
      Cytochrome c oxidase, organism-specific biosystemStructural complex; Energy metabolism; ATP synthesis
    • Cytochrome c oxidase, conserved biosystem (from KEGG)
      Cytochrome c oxidase, conserved biosystemStructural complex; Energy metabolism; ATP synthesis
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Oxidative phosphorylation, organism-specific biosystem (from KEGG)
      Oxidative phosphorylation, organism-specific biosystem
      Oxidative phosphorylation
    • Oxidative phosphorylation, conserved biosystem (from KEGG)
      Oxidative phosphorylation, conserved biosystem
      Oxidative phosphorylation
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...

    General gene information

    Homology

    • Homologs of the COX2 gene: The COX2 gene is conserved in human, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, rice, and frog.

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001643.1 Reference assembly

      Range
      7003..7686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_008189.1 cytochrome c oxidase subunit II [Pan troglodytes]

      See identical proteins and their annotated locations for NP_008189.1

      Status: VALIDATED

      UniProtKB/Swiss-Prot
      P50690
      UniProtKB/TrEMBL
      B0LFN4
      Conserved Domains (3) summary
      MTH00098
      Location:1227
      COX2; cytochrome c oxidase subunit II; Validated
      cd13912
      Location:93221
      CcO_II_C; C-terminal domain of Cytochrome c Oxidase subunit II
      pfam02790
      Location:583
      COX2_TM; Cytochrome C oxidase subunit II, transmembrane domain
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