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    Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [ Mus musculus (house mouse) ]

    Gene ID: 66945, updated on 12-Aug-2018

    Summary

    Official Symbol
    Sdhaprovided by MGI
    Official Full Name
    succinate dehydrogenase complex, subunit A, flavoprotein (Fp)provided by MGI
    Primary source
    MGI:MGI:1914195
    See related
    Ensembl:ENSMUSG00000021577 Vega:OTTMUSG00000030724
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FP; SDH2; SDHF; C81073; 4921513A11; 1500032O14Rik; 2310034D06Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 297.9), kidney adult (RPKM 187.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Sdha in Genome Data Viewer
    Location:
    13; 13 C1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (74322255..74350240, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (74459703..74487688, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene aryl-hydrocarbon receptor repressor Neighboring gene programmed cell death 6 Neighboring gene coiled-coil domain containing 127 Neighboring gene leucine rich repeat containing 14B Neighboring gene zinc finger protein 72 Neighboring gene BCL2-like 13 (apoptosis facilitator) pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    succinate dehydrogenase (ubiquinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    succinate dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
     
    succinate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to succinate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    anaerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial electron transport, succinate to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    respiratory electron transport chain ISO
    Inferred from Sequence Orthology
    more info
     
    succinate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane HDA PubMed 
    mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane succinate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
    Names
    flavoprotein subunit of complex II
    NP_075770.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023281.1NP_075770.1  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_075770.1

      Status: VALIDATED

      Source sequence(s)
      AK010561, AK034928
      Consensus CDS
      CCDS26643.1
      UniProtKB/Swiss-Prot
      Q8K2B3
      Related
      ENSMUSP00000022062.7, OTTMUSP00000039973, ENSMUST00000022062.7, OTTMUST00000076054
      Conserved Domains (3) summary
      PTZ00139
      Location:35664
      PTZ00139; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Provisional
      pfam02910
      Location:513664
      Succ_DH_flav_C; Fumarate reductase flavoprotein C-term
      cl21454
      Location:85518
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      74322255..74350240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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