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    Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 60597, updated on 5-Aug-2018

    Summary

    Official Symbol
    Mapk8ip2provided by MGI
    Official Full Name
    mitogen-activated protein kinase 8 interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1926555
    See related
    Ensembl:ENSMUSG00000022619 Vega:OTTMUSG00000032609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IB2; Jip2; R75148; AI847694; AW049958; 3230402N03Rik
    Expression
    Biased expression in cerebellum adult (RPKM 62.8), cortex adult (RPKM 45.8) and 7 other tissues See more
    Orthologs

    Genomic context

    See Mapk8ip2 in Genome Data Viewer
    Location:
    15; 15 E3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (89453911..89462447)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (89284342..89292878)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44502 Neighboring gene RIKEN cDNA C730034F03 gene Neighboring gene choline kinase beta Neighboring gene RIKEN cDNA C230037L18 gene Neighboring gene arylsulfatase A Neighboring gene predicted gene, 41381

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    MAP-kinase scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    nonassociative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of AMPA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of NMDA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of signaling receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    C-Jun-amino-terminal kinase-interacting protein 2
    Names
    IB-2
    JIP-2
    JNK MAP kinase scaffold protein 2
    JNK-interacting protein 2
    islet-brain-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021921.3NP_068740.3  C-Jun-amino-terminal kinase-interacting protein 2

      See identical proteins and their annotated locations for NP_068740.3

      Status: VALIDATED

      Source sequence(s)
      AC137513, AK158968, BC029704, CA317486
      Consensus CDS
      CCDS27752.1
      UniProtKB/Swiss-Prot
      Q9ERE9
      UniProtKB/TrEMBL
      Q548W8, Q6PIT2
      Related
      ENSMUSP00000023291.5, OTTMUSP00000043322, ENSMUST00000023291.5, OTTMUST00000081091
      Conserved Domains (2) summary
      cd11942
      Location:614668
      SH3_JIP2; Src homology 3 domain of JNK-interacting protein 2
      cd01212
      Location:685830
      PTB_JIP; JNK-interacting protein-like (JIP) Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      89453911..89462447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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