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    Sept3 septin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56003, updated on 12-Aug-2018

    Summary

    Official Symbol
    Sept3provided by RGD
    Official Full Name
    septin 3provided by RGD
    Primary source
    RGD:621745
    See related
    Ensembl:ENSRNOG00000007686
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sep3
    Summary
    GTPase enzyme that is a substrate for type I cGMP-dependent protein kinase [RGD, Feb 2006]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Brain (RPKM 296.4) and Testes (RPKM 25.4) See more
    Orthologs

    Genomic context

    See Sept3 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (123506535..123526542)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (123491254..123511261)

    Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene hypothetical protein LOC688613 Neighboring gene uncharacterized LOC108351520 Neighboring gene WBP2 N-terminal like Neighboring gene alpha-N-acetylgalactosaminidase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex scaffold activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    presynaptic cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin filament array IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    neuronal-specific septin-3
    Names
    G-septin alpha
    P40

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019375.1NP_062248.1  neuronal-specific septin-3

      See identical proteins and their annotated locations for NP_062248.1

      Status: PROVISIONAL

      Source sequence(s)
      AF111179
      UniProtKB/Swiss-Prot
      Q9WU34
      Related
      ENSRNOP00000010491.5, ENSRNOT00000010491.6
      Conserved Domains (2) summary
      cd01850
      Location:59333
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:42329
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

      Range
      123506535..123526542
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000075.1 Alternate Rn_Celera

      Range
      110104873..110124400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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