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    syk spleen tyrosine kinase [ Danio rerio (zebrafish) ]

    Gene ID: 405769, updated on 3-Oct-2019

    Summary

    Official Symbol
    sykprovided by ZNC
    Official Full Name
    spleen tyrosine kinaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040702-3
    See related
    Ensembl:ENSDARG00000008186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Orthologs

    Genomic context

    See syk in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (5533840..5591965, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (5533536..5591675, complement)
    103 previous assembly Zv9 (GCF_000002035.4) 10 NC_007121.5 (5538284..5595322, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene nuclear factor, interleukin 3 regulated Neighboring gene AU RNA binding protein/enoyl-CoA hydratase Neighboring gene DIRAS family GTPase 2 Neighboring gene PDZ and pleckstrin homology domains 1 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    lymphangiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration involved in sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase SYK
    Names
    spleen protein tyrosine kinase
    NP_998008.2
    XP_005155595.1
    XP_005155596.1
    XP_021334822.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212843.2NP_998008.2  tyrosine-protein kinase SYK

      Status: VALIDATED

      Source sequence(s)
      CD284981, CU466285, FP102769
      UniProtKB/TrEMBL
      A0A0R4IBB3
      Related
      ENSDARP00000122788.4, ENSDART00000141943.4
      Conserved Domains (3) summary
      cd05116
      Location:325581
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:8111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:159260
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      5533840..5591965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155539.4XP_005155596.1  tyrosine-protein kinase SYK isoform X1

      See identical proteins and their annotated locations for XP_005155596.1

      UniProtKB/TrEMBL
      F1QFN4
      Conserved Domains (4) summary
      cd05116
      Location:348604
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:8111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:159260
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:349599
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_021479147.1XP_021334822.1  tyrosine-protein kinase SYK isoform X2

      Related
      ENSDARP00000132135.1, ENSDART00000164558.2
      Conserved Domains (3) summary
      cd05116
      Location:325581
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:8111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:159260
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
    3. XM_005155538.4XP_005155595.1  tyrosine-protein kinase SYK isoform X1

      See identical proteins and their annotated locations for XP_005155595.1

      UniProtKB/TrEMBL
      F1QFN4
      Related
      ENSDARP00000003321.7, ENSDART00000005292.8
      Conserved Domains (4) summary
      cd05116
      Location:348604
      PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
      cd09938
      Location:8111
      SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
      cd10401
      Location:159260
      SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
      pfam07714
      Location:349599
      Pkinase_Tyr; Protein tyrosine kinase
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