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    CAPZB capping actin protein of muscle Z-line beta subunit [ Gallus gallus (chicken) ]

    Gene ID: 396418, updated on 14-Feb-2019

    Summary

    Symbol
    CAPZBprovided by CGNC
    Full Name
    capping actin protein of muscle Z-line beta subunitprovided by CGNC
    Primary source
    CGNC:2959
    See related
    Ensembl:ENSGALG00000004034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs

    Genomic context

    See CAPZB in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    104 current GRCg6a (GCF_000002315.5) 21 NC_006108.5 (4686546..4739397, complement)
    103 previous assembly Gallus_gallus-5.0 (GCF_000002315.4) 21 NC_006108.4 (4679429..4732261, complement)
    102 previous assembly Gallus_gallus-4.0 (GCF_000002315.3) 21 NC_006108.3 (4679326..4732155, complement)

    Chromosome 21 - NC_006108.5Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) Neighboring gene PQ loop repeat containing 2 Neighboring gene uncharacterized LOC107054913 Neighboring gene mitochondrial inner membrane organizing system 1

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    F-actin capping protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    brush border IEA
    Inferred from Electronic Annotation
    more info
     
    cortical cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    capping protein (actin filament) muscle Z-line, beta
    Names
    F-actin-capping protein subunit beta
    actin-capping protein Z (cap-Z) beta subunit
    beta-actinin subunit II
    capZ 36/32
    capZ B1 and B2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173529.1NP_001167000.1  capping protein (actin filament) muscle Z-line, beta isoform 2

      See identical proteins and their annotated locations for NP_001167000.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AADN05000197
      UniProtKB/Swiss-Prot
      P14315
      Related
      ENSGALP00000006414.3, ENSGALT00000006424.5
      Conserved Domains (1) summary
      pfam01115
      Location:11239
      F_actin_cap_B; F-actin capping protein, beta subunit
    2. NM_205437.2NP_990768.1  capping protein (actin filament) muscle Z-line, beta isoform 1

      See identical proteins and their annotated locations for NP_990768.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AADN05000197
      UniProtKB/Swiss-Prot
      P14315
      Related
      ENSGALP00000006415.4, ENSGALT00000006425.5
      Conserved Domains (1) summary
      pfam01115
      Location:11239
      F_actin_cap_B; F-actin capping protein, beta subunit

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCg6a Primary Assembly

    Genomic

    1. NC_006108.5 Reference GRCg6a Primary Assembly

      Range
      4686546..4739397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015296835.2XP_015152321.1  capping protein (actin filament) muscle Z-line, beta isoform X1

      UniProtKB/Swiss-Prot
      P14315
      Related
      ENSGALP00000049427.2, ENSGALT00000061238.2
      Conserved Domains (1) summary
      pfam01115
      Location:11239
      F_actin_cap_B; F-actin capping protein, beta subunit
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