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    gclm glutamate-cysteine ligase, modifier subunit [ Danio rerio (zebrafish) ]

    Gene ID: 333974, updated on 18-Jan-2020

    Summary

    Official Symbol
    gclmprovided by ZNC
    Official Full Name
    glutamate-cysteine ligase, modifier subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5906
    See related
    Ensembl:ENSDARG00000018953
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    GLCLR; zgc:55903; id:ibd3182; wu:fi24c07
    Orthologs

    Genomic context

    See gclm in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (15269341..15277252)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (15231637..15239547)
    103 previous assembly Zv9 (GCF_000002035.4) 8 NC_007119.5 (15786374..15794203)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene zgc:171480 Neighboring gene solute carrier family 5 member 9 Neighboring gene deoxynucleotidyltransferase, terminal, interacting protein 2 Neighboring gene spermatogenesis associated 6

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamate-cysteine ligase catalytic subunit binding IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    glutathione biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutathione biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glutamate-cysteine ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    glutamate-cysteine ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    glutamate--cysteine ligase regulatory subunit
    NP_956139.1
    XP_009302077.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199845.1NP_956139.1  glutamate--cysteine ligase regulatory subunit

      See identical proteins and their annotated locations for NP_956139.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044532
      UniProtKB/TrEMBL
      Q803D0
      Related
      ENSDARP00000023515.6, ENSDART00000020386.7
      Conserved Domains (1) summary
      cl00470
      Location:85213
      Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      15269341..15277252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009303802.3XP_009302077.1  glutamate--cysteine ligase regulatory subunit isoform X1

      Conserved Domains (1) summary
      cl00470
      Location:85255
      Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
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