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    Ica1l islet cell autoantigen 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316432, updated on 13-Aug-2019

    Summary

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    Official Symbol
    Ica1lprovided by RGD
    Official Full Name
    islet cell autoantigen 1-likeprovided by RGD
    Primary source
    RGD:735110
    See related
    Ensembl:ENSRNOG00000017258
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Testes (RPKM 88.7), Brain (RPKM 63.1) and 9 other tissues See more
    Orthologs
    human mouse all

    Genomic context

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    See Ica1l in Genome Data Viewer
    Location:
    9q31-q32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (66788094..66848958, complement)
    106 current Rn_Celera (GCF_000002265.2) 9 AC_000077.1 (58848507..58883908, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (66599967..66659239, complement)

    Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene pseudogene for diazepam binding inhibitor 1 Neighboring gene family with sequence similarity 117, member B Neighboring gene WD repeat domain 12 Neighboring gene calcium responsive transcription factor Neighboring gene neurobeachin-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis. He J, et al. J Cell Sci, 2015 Oct 15. PMID 26306493
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
      Title: ICA1L forms BAR-domain complexes with PICK1 and is crucial for acrosome formation in spermiogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    spermatid development IEA
    Inferred from Electronic Annotation
    more info
    		  
    spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    islet cell autoantigen 1-like protein
    Names
    Ica69-related protein
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 15 protein homolog
    islet cell autoantigen 1, 69kDa-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199400.1 → NP_955432.1  islet cell autoantigen 1-like protein

      See identical proteins and their annotated locations for NP_955432.1

      Status: PROVISIONAL

      Source sequence(s)
      AY491990
      UniProtKB/Swiss-Prot
      Q6RUG5
      Conserved Domains (2) summary
      pfam04629
      Location:254 → 435
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:46 → 248
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

      Range
      66788094..66848958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596464.1 → XP_017451953.1  islet cell autoantigen 1-like protein isoform X5

    2. XM_017596466.1 → XP_017451955.1  islet cell autoantigen 1-like protein isoform X5

    3. XM_008767111.1 → XP_008765333.1  islet cell autoantigen 1-like protein isoform X2

      Conserved Domains (2) summary
      pfam04629
      Location:270 → 484
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 264
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_006244999.2 → XP_006245061.1  islet cell autoantigen 1-like protein isoform X7

      Conserved Domains (2) summary
      pfam04629
      Location:276 → 449
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    5. XM_006244998.2 → XP_006245060.1  islet cell autoantigen 1-like protein isoform X6

      Conserved Domains (2) summary
      pfam04629
      Location:276 → 457
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    6. XM_006244995.2 → XP_006245057.1  islet cell autoantigen 1-like protein isoform X3

      UniProtKB/TrEMBL
      A0A0H2UHX6
      Related
      ENSRNOP00000045103.2, ENSRNOT00000041546.2
      Conserved Domains (2) summary
      pfam04629
      Location:276 → 474
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    7. XM_017596461.1 → XP_017451950.1  islet cell autoantigen 1-like protein isoform X4

    8. XM_006244994.2 → XP_006245056.1  islet cell autoantigen 1-like protein isoform X1

      Conserved Domains (2) summary
      pfam04629
      Location:276 → 490
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_017596462.1 → XP_017451951.1  islet cell autoantigen 1-like protein isoform X5

    10. XM_017596463.1 → XP_017451952.1  islet cell autoantigen 1-like protein isoform X5

    11. XM_008767112.2 → XP_008765334.1  islet cell autoantigen 1-like protein isoform X9

      Conserved Domains (2) summary
      pfam04629
      Location:276 → 316
      ICA69; Islet cell autoantigen ICA69, C-terminal domain
      cl12013
      Location:68 → 270
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    12. XM_017596465.1 → XP_017451954.1  islet cell autoantigen 1-like protein isoform X8

    Alternate Rn_Celera

    Genomic

    1. AC_000077.1 Alternate Rn_Celera

      Range
      58848507..58883908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RUG5.1 GenPept UniProtKB/Swiss-Prot:Q6RUG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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