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    Rab18 RAB18, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307039, updated on 13-Jan-2020

    Summary

    Official Symbol
    Rab18provided by RGD
    Official Full Name
    RAB18, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1308905
    See related
    Ensembl:ENSRNOG00000018972
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Brain (RPKM 439.1), Liver (RPKM 422.1) and 9 other tissues See more
    Orthologs

    Genomic context

    See Rab18 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (59844781..59876170)
    106 current Rn_Celera (GCF_000002265.2) 17 AC_000085.1 (56284171..56315512)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (61632659..61664794)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene similar to Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS) Neighboring gene similar to ankyrin repeat domain 26 Neighboring gene similar to ribosomal protein S14 Neighboring gene uncharacterized LOC103694111 Neighboring gene uncharacterized LOC108348580

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC109292

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    GDP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    endoplasmic reticulum tubular network organization IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid droplet organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum tubular network IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012468.1NP_001012486.1  ras-related protein Rab-18

      See identical proteins and their annotated locations for NP_001012486.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089957
      UniProtKB/Swiss-Prot
      Q5EB77
      Related
      ENSRNOP00000025828.3, ENSRNOT00000025828.4
      Conserved Domains (2) summary
      smart00175
      Location:9172
      RAB; Rab subfamily of small GTPases
      cd01863
      Location:9169
      Rab18; Rab GTPase family 18 (Rab18)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      59844781..59876170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      56284171..56315512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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