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    Rcor2 REST corepressor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305811, updated on 2-Oct-2018

    Summary

    Official Symbol
    Rcor2provided by RGD
    Official Full Name
    REST corepressor 2provided by RGD
    Primary source
    RGD:1359467
    See related
    Ensembl:ENSRNOG00000060849
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Heart (RPKM 88.3), Muscle (RPKM 34.6) and 8 other tissues See more
    Orthologs

    Genomic context

    See Rcor2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222513970..222525356)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 15 NC_005114.3 (23568509..23574620)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 8A Neighboring gene heterogeneous nuclear ribonucleoprotein R-like Neighboring gene N(alpha)-acetyltransferase 40, NatD catalytic subunit Neighboring gene microtubule affinity regulating kinase 2 Neighboring gene spindlin interactor and repressor of chromatin binding

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    General gene information

    Markers

    Homology

    Clone Names

    • MGC105529

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription regulatory region DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    REST corepressor 2
    Names
    RE1-silencing transcription factor (REST) co-repressor 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013994.1NP_001014016.1  REST corepressor 2

      See identical proteins and their annotated locations for NP_001014016.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089209
      UniProtKB/Swiss-Prot
      Q5FWT8
      Related
      ENSRNOP00000072780.1, ENSRNOT00000083585.1
      Conserved Domains (4) summary
      smart00717
      Location:331376
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:331374
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:4698
      ELM2; ELM2 domain
      cl21498
      Location:134178
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      222513970..222525356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760113.2XP_008758335.1  REST corepressor 2 isoform X1

      Conserved Domains (4) summary
      smart00717
      Location:382427
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:382425
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:97149
      ELM2; ELM2 domain
      cl21498
      Location:185229
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    2. XM_008760115.2XP_008758337.1  REST corepressor 2 isoform X2

      See identical proteins and their annotated locations for XP_008758337.1

      UniProtKB/Swiss-Prot
      Q5FWT8
      Conserved Domains (4) summary
      smart00717
      Location:331376
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:331374
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:4698
      ELM2; ELM2 domain
      cl21498
      Location:134178
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    3. XM_008760114.2XP_008758336.1  REST corepressor 2 isoform X2

      See identical proteins and their annotated locations for XP_008758336.1

      UniProtKB/Swiss-Prot
      Q5FWT8
      Conserved Domains (4) summary
      smart00717
      Location:331376
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:331374
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam01448
      Location:4698
      ELM2; ELM2 domain
      cl21498
      Location:134178
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      201987882..201993898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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