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    Map3k3 mitogen activated protein kinase kinase kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303604, updated on 10-Oct-2019

    Summary

    Official Symbol
    Map3k3provided by RGD
    Official Full Name
    mitogen activated protein kinase kinase kinase 3provided by RGD
    Primary source
    RGD:1304575
    See related
    Ensembl:ENSRNOG00000061424
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Expression
    Biased expression in Thymus (RPKM 222.5), Lung (RPKM 198.0) and 9 other tissues See more
    Orthologs

    Genomic context

    See Map3k3 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94280703..94349372)
    106 current Rn_Celera (GCF_000002265.2) 10 AC_000078.1 (89696294..89764939)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (94029306..94098042)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of cytochrome c oxidase I Neighboring gene LIM domain containing 2 Neighboring gene STE20 related adaptor alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    biological_process ND
    No biological Data available
    more info
     
    blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell proliferation in bone marrow IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation in bone marrow ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 3
    NP_001100528.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107058.2NP_001100528.1  mitogen-activated protein kinase kinase kinase 3

      See identical proteins and their annotated locations for NP_001100528.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168979
      UniProtKB/TrEMBL
      B5DF98
      Related
      ENSRNOP00000074780.1, ENSRNOT00000088656.1
      Conserved Domains (3) summary
      cd06405
      Location:45123
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      smart00220
      Location:362621
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06625
      Location:361621
      STKc_MEKK3_like; Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      94280703..94349372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      89696294..89764939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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