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    Rab3a RAB3A, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25531, updated on 10-Oct-2019

    Summary

    Official Symbol
    Rab3aprovided by RGD
    Official Full Name
    RAB3A, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:3528
    See related
    Ensembl:ENSRNOG00000019433
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RAB3
    Summary
    regulated synaptic vesicle endocytosis [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 1072.2), Heart (RPKM 150.1) and 4 other tissues See more
    Orthologs

    Genomic context

    See Rab3a in Genome Data Viewer
    Location:
    16p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20435098..20439206, complement)
    106 current Rn_Celera (GCF_000002265.2) 16 AC_000084.1 (18876401..18880512, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (20292166..20296274, complement)

    Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348390 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene IFI30, lysosomal thiol reductase Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene phosphodiesterase 4C Neighboring gene IQ motif containing N

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GDP-dissociation inhibitor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    myosin V binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin V binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Rab protein signal transduction IC
    Inferred by Curator
    more info
    PubMed 
    acrosomal vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    acrosomal vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium ion regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    evoked neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
     
    evoked neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    exocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lung development IEA
    Inferred from Electronic Annotation
    more info
     
    lung development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    lysosome localization IEA
    Inferred from Electronic Annotation
    more info
     
    lysosome localization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    maintenance of presynaptic active zone structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    maintenance of presynaptic active zone structure ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuromuscular synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane repair IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane repair ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of regulated secretory pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of regulated secretory pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of plasma membrane repair IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of plasma membrane repair ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of short-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of short-term neuronal synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of synaptic vesicle fusion to presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of synaptic vesicle fusion to presynaptic active zone membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of synaptic vesicle priming IDA
    Inferred from Direct Assay
    more info
    PubMed 
    respiratory system process IEA
    Inferred from Electronic Annotation
    more info
     
    respiratory system process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to electrical stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sensory perception of touch IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of touch ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic vesicle clustering IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle clustering ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic vesicle maturation IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle maturation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synaptic vesicle recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic vesicle transport IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vesicle docking involved in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    anchored component of synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    PubMed 
    anchored component of synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anchored component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anchored component of synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    presynaptic active zone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ras-related protein Rab-3A
    Names
    Ras-related small GTP binding protein 3A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013018.2NP_037150.2  ras-related protein Rab-3A

      See identical proteins and their annotated locations for NP_037150.2

      Status: PROVISIONAL

      Source sequence(s)
      BC087580
      UniProtKB/Swiss-Prot
      P63012
      Related
      ENSRNOP00000026392.3, ENSRNOT00000026391.6
      Conserved Domains (1) summary
      cd01865
      Location:22186
      Rab3; Rab GTPase family 3 contains Rab3A, Rab3B, Rab3C and Rab3D

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

      Range
      20435098..20439206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000084.1 Alternate Rn_Celera

      Range
      18876401..18880512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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