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    cdc20 DNA polymerase epsilon catalytic subunit Pol2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540627, updated on 5-Aug-2018

    Summary

    Gene symbol
    cdc20
    Gene description
    DNA polymerase epsilon catalytic subunit Pol2
    Locus tag
    SPBC25H2.13c
    Gene type
    protein coding
    RNA name
    DNA polymerase epsilon catalytic subunit Pol2
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    pol2

    Genomic context

    See cdc20 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (3253690..3260706)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene UNC-50 family protein Neighboring gene putative respiratory chain complex IV assembly protein Cox20 Neighboring gene chaperonin-containing T-complex eta subunit Cct7 Neighboring gene SAGA complex bromodomain subunit Spt7 Neighboring gene putative tRNA acetyltransferase

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-directed DNA polymerase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA 3'-5' exodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication proofreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    base-excision repair, gap-filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leading strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT mitotic DNA replication checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic DNA replication leading strand elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide-excision repair, DNA gap filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of chromatin silencing at centromere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    premeiotic DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of CENP-A containing nucleosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of chromatin silencing by small RNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    epsilon DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear replication fork IC
    Inferred by Curator
    more info
     

    General protein information

    Preferred Names
    DNA polymerase epsilon catalytic subunit Pol2
    NP_596354.1

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3253690..3260706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022274.2NP_596354.1  DNA polymerase epsilon catalytic subunit Pol2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596354.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P87154
      Conserved Domains (4) summary
      cd05779
      Location:269472
      DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
      cd05535
      Location:5311151
      POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...
      COG0417
      Location:1051163
      PolB; DNA polymerase elongation subunit (family B) [Replication, recombination and repair]
      pfam08490
      Location:15001886
      DUF1744; Domain of unknown function (DUF1744)
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