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    Abcc2 ATP binding cassette subfamily C member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25303, updated on 8-Jan-2020

    Summary

    Official Symbol
    Abcc2provided by RGD
    Official Full Name
    ATP binding cassette subfamily C member 2provided by RGD
    Primary source
    RGD:2366
    See related
    Ensembl:ENSRNOG00000046727
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mrp; Mrp2; cMRP; Cmoat
    Summary
    multispecific organic anion transporter; mutation may be responsible for conjugated hyperbilirubinemia in the TR- rat, which is a model for human Dubin-Johnson syndrome [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 1630.1) See more
    Orthologs

    Genomic context

    See Abcc2 in Genome Data Viewer
    Location:
    1q54
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (263554426..263612556)
    106 current Rn_Celera (GCF_000002265.2) 1 AC_000069.1 (238483399..238539595)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (270999832..271057750)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene cutC copper transporter Neighboring gene cystatin-B-like Neighboring gene dynamin binding protein Neighboring gene casein kinase II subunit alpha'-like Neighboring gene carboxypeptidase N subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity, coupled to transmembrane movement of substances IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity, coupled to transmembrane movement of substances ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ATPase activity, coupled to transmembrane movement of substances ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    organic anion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    xenobiotic transmembrane transporting ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    antibiotic metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    benzylpenicillin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bile acid and bile salt transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    bile acid and bile salt transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    canalicular bile acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular chloride ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to dexamethasone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interleukin-6 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    detoxification of mercury ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drug transmembrane export IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drug transport across blood-brain barrier IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    drug transport across blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female pregnancy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    leukotriene transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mercury ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organic anion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    prostaglandin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to antineoplastic agent IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to arsenic-containing substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estrogen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to glucagon IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to heat IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to methotrexate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to steroid hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    thyroid hormone transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transepithelial transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transepithelial transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    xenobiotic catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    brush border membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intercellular canaliculus IEA
    Inferred from Electronic Annotation
    more info
     
    intercellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    canalicular multispecific organic anion transporter 1
    Names
    ATP-binding cassette sub-family C member 2
    ATP-binding cassette, sub-family C (CFTR/MRP), member 2
    ATP-binding cassette, subfamily C (CFTR/MRP), member 2
    cMrp2/cMoat canalicular apical conjugate export pump
    calicular multispecific organic anion transporter
    canalicular multidrug resistance protein
    multidrug resistance-associated protein 2
    NP_036965.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012833.2NP_036965.1  canalicular multispecific organic anion transporter 1

      See identical proteins and their annotated locations for NP_036965.1

      Status: REVIEWED

      Source sequence(s)
      AABR07006900, L49379, X96393
      UniProtKB/Swiss-Prot
      Q63120
      Related
      ENSRNOP00000064799.1, ENSRNOT00000070861.2
      Conserved Domains (4) summary
      TIGR00957
      Location:71533
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:12941514
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:633834
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:9791245
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      263554426..263612556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      238483399..238539595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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