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    Mas1 MAS1 proto-oncogene, G protein-coupled receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25153, updated on 18-Sep-2018

    Summary

    Official Symbol
    Mas1provided by RGD
    Official Full Name
    MAS1 proto-oncogene, G protein-coupled receptorprovided by RGD
    Primary source
    RGD:3049
    See related
    Ensembl:ENSRNOG00000014971
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mgra; c-mas
    Summary
    oncogene; may be involved in function or development of neural tissues [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 15.2), Heart (RPKM 5.7) and 7 other tissues See more
    Orthologs

    Genomic context

    See Mas1 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48076761..48108218)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (51644462..51675365, complement)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene PARN like, ribonuclease domain containing 1 Neighboring gene MAS1 proto-oncogene like, G protein-coupled receptor Neighboring gene insulin-like growth factor 2 receptor Neighboring gene solute carrier family 22 member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    angiotensin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    angiotensin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of NF-kappaB-inducing kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of NF-kappaB-inducing kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    angiotensin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to peptide hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hippocampus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    male gonad development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of inositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase C signaling IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to gonadotropin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    proto-oncogene Mas
    Names
    MAS proto-oncogene
    MAS1 oncogene
    Mas-related G protein-coupled receptor a
    angiotensin-(1-7) receptor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012757.2NP_036889.1  proto-oncogene Mas

      See identical proteins and their annotated locations for NP_036889.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078884
      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
      Related
      ENSRNOP00000020100.4, ENSRNOT00000020100.5
      Conserved Domains (1) summary
      pfam00001
      Location:48279
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      48076761..48108218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017588807.1XP_017444296.1  proto-oncogene Mas isoform X1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
      Conserved Domains (1) summary
      pfam00001
      Location:48279
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_006227860.3XP_006227922.1  proto-oncogene Mas isoform X1

      See identical proteins and their annotated locations for XP_006227922.1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
      Conserved Domains (1) summary
      pfam00001
      Location:48279
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. XM_017588808.1XP_017444297.1  proto-oncogene Mas isoform X1

      UniProtKB/Swiss-Prot
      P12526
      UniProtKB/TrEMBL
      W8W3M4
      Conserved Domains (1) summary
      pfam00001
      Location:48279
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      43680754..43711122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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