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    Prl prolactin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24683, updated on 2-Oct-2018

    Summary

    Official Symbol
    Prlprovided by RGD
    Official Full Name
    prolactinprovided by RGD
    Primary source
    RGD:3403
    See related
    Ensembl:ENSRNOG00000017374
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gha1; PRLB; Prol; PRLSD1; Prl1a1; RNPROL; RATPRLSD1
    Summary
    induces lactation; may facilitate decidual growth and placentation; promotes prostate epithelial cell proliferation [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 6.5) See more

    Genomic context

    See Prl in Genome Data Viewer
    Location:
    17p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (39814236..39824299, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (41720751..41730813, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene prolactin-3D1 Neighboring gene Prolactin family 3, subfamily d, member 1 Neighboring gene 60S ribosomal protein L19-like Neighboring gene similar to thymine DNA glycosylase isoform 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    prolactin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    prolactin receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    female pregnancy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    lactation TAS
    Traceable Author Statement
    more info
    PubMed 
    mammary gland development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mammary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    maternal behavior ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal response to stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    ovulation cycle IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    parturition IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of JAK-STAT cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of lactation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of pri-miRNA transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of pri-miRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prolactin
    Names
    growth hormone a1
    prolactin family 1, subfamily a, member 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012629.1NP_036761.1  prolactin precursor

      See identical proteins and their annotated locations for NP_036761.1

      Status: PROVISIONAL

      Source sequence(s)
      AF022935
      UniProtKB/Swiss-Prot
      P01237
      UniProtKB/TrEMBL
      B5DEM6
      Related
      ENSRNOP00000023412.3, ENSRNOT00000023412.4
      Conserved Domains (1) summary
      cd10288
      Location:30226
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      39814236..39824299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253912.2XP_006253974.1  prolactin isoform X1

      See identical proteins and their annotated locations for XP_006253974.1

      UniProtKB/TrEMBL
      B2RYT1
      Conserved Domains (1) summary
      cd10288
      Location:29225
      prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      37551071..37561021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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