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    Bcl2 BCL2, apoptosis regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24224, updated on 8-Dec-2018

    Summary

    Official Symbol
    Bcl2provided by RGD
    Official Full Name
    BCL2, apoptosis regulatorprovided by RGD
    Primary source
    RGD:2199
    See related
    Ensembl:ENSRNOG00000002791
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bcl-2
    Summary
    an anti-apoptotic protein; involved in inhibiting cell death in many different cell types [RGD, Feb 2006]
    Expression
    Biased expression in Spleen (RPKM 83.4), Thymus (RPKM 72.9) and 9 other tissues See more
    Orthologs

    Genomic context

    See Bcl2 in Genome Data Viewer
    Location:
    13p11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (26605426..26769374, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (31758213..31920775, complement)

    Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene serpin B12-like Neighboring gene uncharacterized LOC108352519 Neighboring gene uncharacterized LOC102552849 Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene vacuolar protein sorting 4 homolog B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    • AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • AGE-RAGE signaling pathway in diabetic complications, conserved biosystem (from KEGG)
      AGE-RAGE signaling pathway in diabetic complications, conserved biosystemAdvanced glycation end products (AGEs) are a complex group of compounds produced through the non-enzymatic glycation and oxidation of proteins, lipids and nucleic acids, primarily due to aging and un...
    • ATM Signaling Pathway, organism-specific biosystem (from WikiPathways)
      ATM Signaling Pathway, organism-specific biosystem
      ATM Signaling Pathway
    • Activation of BAD and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation of BAD and translocation to mitochondria, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
      Activation of BH3-only proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
      Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Apoptosis - multiple species, conserved biosystem (from KEGG)
      Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cholinergic synapse, organism-specific biosystem (from KEGG)
      Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
    • Colorectal cancer, organism-specific biosystem (from KEGG)
      Colorectal cancer, organism-specific biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • Colorectal cancer, conserved biosystem (from KEGG)
      Colorectal cancer, conserved biosystemColorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in ...
    • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
      EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
    • Endocrine resistance, organism-specific biosystem (from KEGG)
      Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Endocrine resistance, conserved biosystem (from KEGG)
      Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Estrogen signaling, organism-specific biosystem (from WikiPathways)
      Estrogen signaling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
      Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
    • Focal Adhesion, organism-specific biosystem (from WikiPathways)
      Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, organism-specific biosystem (from KEGG)
      Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • Focal adhesion, conserved biosystem (from KEGG)
      Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
    • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
      HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
    • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
      Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
    • Hedgehog signaling pathway, conserved biosystem (from KEGG)
      Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) signaling pathway has numerous roles in the control of cell proliferation, tissue patterning, stem cell maintenance and development. The primary cilium is an important center for tr...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Inflammasomes, organism-specific biosystem (from REACTOME)
      Inflammasomes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Platinum drug resistance, organism-specific biosystem (from KEGG)
      Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Platinum drug resistance, conserved biosystem (from KEGG)
      Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
      Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
    • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
      Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
    • The NLRP1 inflammasome, organism-specific biosystem (from REACTOME)
      The NLRP1 inflammasome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
      Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    BH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    BH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    BH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase 2A binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    B cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    B cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    CD8-positive, alpha-beta T cell lineage commitment IEA
    Inferred from Electronic Annotation
    more info
     
    CD8-positive, alpha-beta T cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    T cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    T cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    axonogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral fear response IEA
    Inferred from Electronic Annotation
    more info
     
    behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
     
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell aging IEA
    Inferred from Electronic Annotation
    more info
     
    cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to fluoride IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to glucose starvation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose starvation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to organic substance IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic substance ISO
    Inferred from Sequence Orthology
    more info
     
    cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cochlear nucleus development IEA
    Inferred from Electronic Annotation
    more info
     
    cochlear nucleus development ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    developmental pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    ear development IEA
    Inferred from Electronic Annotation
    more info
     
    ear development ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic apoptotic signaling pathway via death domain receptors IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion assembly IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    glial cell apoptotic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    glomerulus development IEA
    Inferred from Electronic Annotation
    more info
     
    glomerulus development ISO
    Inferred from Sequence Orthology
    more info
     
    hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    hair follicle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    homeostasis of number of cells within a tissue IEA
    Inferred from Electronic Annotation
    more info
     
    homeostasis of number of cells within a tissue ISO
    Inferred from Sequence Orthology
    more info
     
    immune system development ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    liver regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    lymphocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    lymphoid progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    lymphoid progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    melanin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    melanin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    melanocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    mesenchymal cell development IEA
    Inferred from Electronic Annotation
    more info
     
    mesenchymal cell development ISO
    Inferred from Sequence Orthology
    more info
     
    metanephros development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephros development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of calcium ion transport into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular pH reduction IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cellular pH reduction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myeloid cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myeloid cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of retinal cell programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of retinal cell programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    oligodendrocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    oocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    organ growth ISO
    Inferred from Sequence Orthology
    more info
     
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    ossification ISO
    Inferred from Sequence Orthology
    more info
     
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    ovarian follicle development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    pigment granule organization IEA
    Inferred from Electronic Annotation
    more info
     
    pigment granule organization ISO
    Inferred from Sequence Orthology
    more info
     
    pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of developmental pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of melanocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of melanocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron maturation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron maturation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of skeletal muscle fiber development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of skeletal muscle fiber development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of developmental pigmentation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glycoprotein biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of growth ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial membrane permeability IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrial membrane permeability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial membrane permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of nitrogen utilization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of nitrogen utilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
     
    release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    release of cytochrome c from mitochondria ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    renal system process IEA
    Inferred from Electronic Annotation
    more info
     
    renal system process ISO
    Inferred from Sequence Orthology
    more info
     
    response to L-ascorbic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to UV-B IEA
    Inferred from Electronic Annotation
    more info
     
    response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    response to aluminum ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to amyloid-beta IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cAMP IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to caffeine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to copper ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to corticosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to erythropoietin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ethanol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to folic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    response to heat IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to inorganic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to iron ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to iron ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    response to monosaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    response to nutrient IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to organic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to phenylpropanoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to steroid hormone ISO
    Inferred from Sequence Orthology
    more info
     
    response to toxic substance ISO
    Inferred from Sequence Orthology
    more info
     
    response to vitamin E IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    spleen development ISO
    Inferred from Sequence Orthology
    more info
     
    thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pore complex IEA
    Inferred from Electronic Annotation
    more info
     
    pore complex ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    apoptosis regulator Bcl-2
    Names
    B cell lymphoma 2 associated oncogene
    B-cell CLL/lymphoma 2
    B-cell leukemia/lymphoma 2
    Bcl-2alpha
    Bcl2-like protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016993.1NP_058689.1  apoptosis regulator Bcl-2

      See identical proteins and their annotated locations for NP_058689.1

      Status: PROVISIONAL

      Source sequence(s)
      L14680
      UniProtKB/Swiss-Prot
      P49950
      Related
      ENSRNOP00000003768.1, ENSRNOT00000003768.2
      Conserved Domains (3) summary
      smart00265
      Location:733
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:78198
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:11236
      bcl-2; apoptosis regulator

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

      Range
      26605426..26769374 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000081.1 Alternate Rn_Celera

      Range
      22550362..22711143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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