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    Apc APC, WNT signaling pathway regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24205, updated on 2-Oct-2018

    Summary

    Official Symbol
    Apcprovided by RGD
    Official Full Name
    APC, WNT signaling pathway regulatorprovided by RGD
    Primary source
    RGD:2123
    See related
    Ensembl:ENSRNOG00000020423
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RATAPC
    Summary
    binds microtubules; may play a role in the regulation of cell polarity [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 510.2), Lung (RPKM 138.6) and 9 other tissues See more
    Orthologs

    Genomic context

    See Apc in Genome Data Viewer
    Location:
    18p12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (27011710..27106323)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (26725560..26820837)

    Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC103694952 Neighboring gene uncharacterized LOC102549857 Neighboring gene signal recognition particle 19kDa-like Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    gamma-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule plus-end binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
     
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway involved in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway involved in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle arrest ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    chromosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    dorsal/ventral pattern formation ISO
    Inferred from Sequence Orthology
    more info
     
    establishment or maintenance of cell polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hair follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    metaphase/anaphase transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    muscle cell cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation involved in prostate gland development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of microtubule depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of microtubule depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of odontogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pancreas development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    pattern specification process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    proximal/distal pattern formation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glutamate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of microtubule-based process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of microtubule-based process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of nitrogen compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    response to alcohol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    skin development ISO
    Inferred from Sequence Orthology
    more info
     
    somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Scrib-APC-beta-catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axonal growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin destruction complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell body fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell-cell adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cell-cell adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection terminus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    adenomatous polyposis coli protein
    Names
    WNT signaling pathway regulator
    adenomatosis polyposis coli

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012499.1NP_036631.1  adenomatous polyposis coli protein

      See identical proteins and their annotated locations for NP_036631.1

      Status: PROVISIONAL

      Source sequence(s)
      D38629
      UniProtKB/Swiss-Prot
      P70478
      Related
      ENSRNOP00000027691.1, ENSRNOT00000027691.3
      Conserved Domains (15) summary
      cd00020
      Location:609729
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16351659
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20332052
      SAMP; SAMP Motif
      pfam05937
      Location:26702842
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22232568
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7301017
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10341133
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12801365
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16601716
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17371837
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18741945
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:463506
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:190273
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

      Range
      27011710..27106323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254506.3XP_006254568.1  adenomatous polyposis coli protein isoform X1

      Conserved Domains (14) summary
      cd00020
      Location:637757
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16631687
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20612080
      SAMP; SAMP Motif
      pfam05937
      Location:26982870
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22512596
      APC_basic; APC basic domain
      pfam11414
      Location:135215
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7581045
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10621161
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:13081393
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16881744
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17651865
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:19021973
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:589621
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:200283
      ATP-synt_B; ATP synthase B/B' CF(0)
    2. XM_006254520.3XP_006254582.1  adenomatous polyposis coli protein isoform X9

      Conserved Domains (14) summary
      cd00020
      Location:536656
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:15621586
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19601979
      SAMP; SAMP Motif
      pfam05937
      Location:25972769
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21502495
      APC_basic; APC basic domain
      pfam11414
      Location:135215
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:657944
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9611060
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12071292
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15871643
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16641764
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18011872
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:488520
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:200283
      ATP-synt_B; ATP synthase B/B' CF(0)
    3. XM_006254513.3XP_006254575.1  adenomatous polyposis coli protein isoform X6

      Conserved Domains (13) summary
      cd00020
      Location:602722
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16281652
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20262045
      SAMP; SAMP Motif
      pfam05937
      Location:26632835
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22162561
      APC_basic; APC basic domain
      pfam11414
      Location:135215
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7231010
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10271126
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12731358
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16531709
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17301830
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18671938
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:554586
      ARM; armadillo repeat [structural motif]
    4. XM_006254510.3XP_006254572.1  adenomatous polyposis coli protein isoform X3

      See identical proteins and their annotated locations for XP_006254572.1

      Conserved Domains (14) summary
      cd00020
      Location:619739
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16451669
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20432062
      SAMP; SAMP Motif
      pfam05937
      Location:26802852
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22332578
      APC_basic; APC basic domain
      pfam11414
      Location:135215
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7401027
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10441143
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12901375
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16701726
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17471847
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18841955
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:473516
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:200283
      ATP-synt_B; ATP synthase B/B' CF(0)
    5. XM_006254508.3XP_006254570.1  adenomatous polyposis coli protein isoform X2

      See identical proteins and their annotated locations for XP_006254570.1

      UniProtKB/TrEMBL
      A0A0G2K8G0
      Conserved Domains (15) summary
      cd00020
      Location:627747
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16531677
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20512070
      SAMP; SAMP Motif
      pfam05937
      Location:26882860
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22412586
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7481035
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10521151
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12981383
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16781734
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17551855
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18921963
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:579611
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:190273
      ATP-synt_B; ATP synthase B/B' CF(0)
    6. XM_006254511.3XP_006254573.1  adenomatous polyposis coli protein isoform X4

      See identical proteins and their annotated locations for XP_006254573.1

      UniProtKB/TrEMBL
      G3V8Q9
      Conserved Domains (15) summary
      cd00020
      Location:609729
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16351659
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20332052
      SAMP; SAMP Motif
      pfam05937
      Location:26702842
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22232568
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7301017
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10341133
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12801365
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16601716
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17371837
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18741945
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:463506
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:190273
      ATP-synt_B; ATP synthase B/B' CF(0)
    7. XM_006254521.3XP_006254583.1  adenomatous polyposis coli protein isoform X10

      Conserved Domains (15) summary
      cd00020
      Location:508628
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:15341558
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19321951
      SAMP; SAMP Motif
      pfam05937
      Location:25692741
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21222467
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:629916
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9331032
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:11791264
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:15591615
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16361736
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:17731844
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:362405
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:190273
      ATP-synt_B; ATP synthase B/B' CF(0)
    8. XM_017600838.1XP_017456327.1  adenomatous polyposis coli protein isoform X8

      Conserved Domains (14) summary
      cd00020
      Location:568688
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:15941618
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19922011
      SAMP; SAMP Motif
      pfam05937
      Location:26292801
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21822527
      APC_basic; APC basic domain
      pfam11414
      Location:66146
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:689976
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9931092
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12391324
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16191675
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16961796
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18331904
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:520552
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:131214
      ATP-synt_B; ATP synthase B/B' CF(0)
    9. XM_006254512.3XP_006254574.1  adenomatous polyposis coli protein isoform X5

      Conserved Domains (14) summary
      cd00020
      Location:607727
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16331657
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20312050
      SAMP; SAMP Motif
      pfam05937
      Location:26682840
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22212566
      APC_basic; APC basic domain
      pfam11414
      Location:105185
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7281015
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10321131
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12781363
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16581714
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17351835
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18721943
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:559591
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:170253
      ATP-synt_B; ATP synthase B/B' CF(0)
    10. XM_006254515.3XP_006254577.1  adenomatous polyposis coli protein isoform X7

      Conserved Domains (14) summary
      cd00020
      Location:587707
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16131637
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20112030
      SAMP; SAMP Motif
      pfam05937
      Location:26482820
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22012546
      APC_basic; APC basic domain
      pfam11414
      Location:85165
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:708995
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10121111
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12581343
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16381694
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17151815
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18521923
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:539571
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:150233
      ATP-synt_B; ATP synthase B/B' CF(0)
    11. XM_006254509.3XP_006254571.1  adenomatous polyposis coli protein isoform X2

      See identical proteins and their annotated locations for XP_006254571.1

      UniProtKB/TrEMBL
      A0A0G2K8G0
      Related
      ENSRNOP00000074593.1, ENSRNOT00000090264.1
      Conserved Domains (15) summary
      cd00020
      Location:627747
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:16531677
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:20512070
      SAMP; SAMP Motif
      pfam05937
      Location:26882860
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:22412586
      APC_basic; APC basic domain
      pfam11414
      Location:125205
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:7481035
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:10521151
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12981383
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16781734
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:17551855
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18921963
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      pfam16689
      Location:455
      APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
      sd00043
      Location:579611
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:190273
      ATP-synt_B; ATP synthase B/B' CF(0)
    12. XM_017600837.1XP_017456326.1  adenomatous polyposis coli protein isoform X8

      Conserved Domains (14) summary
      cd00020
      Location:568688
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:15941618
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19922011
      SAMP; SAMP Motif
      pfam05937
      Location:26292801
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21822527
      APC_basic; APC basic domain
      pfam11414
      Location:66146
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:689976
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9931092
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12391324
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16191675
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16961796
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18331904
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:520552
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:131214
      ATP-synt_B; ATP synthase B/B' CF(0)
    13. XM_017600836.1XP_017456325.1  adenomatous polyposis coli protein isoform X8

      Conserved Domains (14) summary
      cd00020
      Location:568688
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:15941618
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19922011
      SAMP; SAMP Motif
      pfam05937
      Location:26292801
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21822527
      APC_basic; APC basic domain
      pfam11414
      Location:66146
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:689976
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9931092
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12391324
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16191675
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16961796
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18331904
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:520552
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:131214
      ATP-synt_B; ATP synthase B/B' CF(0)
    14. XM_006254518.3XP_006254580.1  adenomatous polyposis coli protein isoform X8

      See identical proteins and their annotated locations for XP_006254580.1

      Conserved Domains (14) summary
      cd00020
      Location:568688
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam05923
      Location:15941618
      APC_crr; APC cysteine-rich region
      pfam05924
      Location:19922011
      SAMP; SAMP Motif
      pfam05937
      Location:26292801
      EB1_binding; EB-1 Binding Domain
      pfam05956
      Location:21822527
      APC_basic; APC basic domain
      pfam11414
      Location:66146
      Suppressor_APC; Adenomatous polyposis coli tumour suppressor protein
      pfam16629
      Location:689976
      Arm_APC_u3; Armadillo-associated region on APC
      pfam16630
      Location:9931092
      APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
      pfam16633
      Location:12391324
      APC_u9; Unstructured region on APC between 1st two creatine-rich regions
      pfam16634
      Location:16191675
      APC_u13; Unstructured region on APC between APC_crr and SAMP
      pfam16635
      Location:16961796
      APC_u14; Unstructured region on APC between SAMP and APC_crr
      pfam16636
      Location:18331904
      APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
      sd00043
      Location:520552
      ARM; armadillo repeat [structural motif]
      cl21478
      Location:131214
      ATP-synt_B; ATP synthase B/B' CF(0)

    Alternate Rn_Celera

    Genomic

    1. AC_000086.1 Alternate Rn_Celera

      Range
      25606119..25663749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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